ประสิทธิภาพของกรดไตรคลอโรอะซีติค 50% ในการลดความลึกของรอยแผลเป็นจากสิว ชนิดหลุมเทียบกับกลุ่มควบคุม / ดวงกมล ทัศนพงศากุล = Efficacy of 50% trichloroacetic acid in reducing depth of ice-pick acne scar in patients compare with control group / Duangkamol Thasanapongsakul
Background : Fifty-percent trichloroacetic acid is medium-depth chemical peeling agent. It has been shown to provide cosmetic benefits by stimulating the production of dermal collagen and reepithelialization. The randomized-control clinical trial proving the efficacy of trichloroacetic acid in reducing depth of ice-pick acne scar has yet been established. Objective: Our purpose was to determine the efficacy of fifty-percent trichloroacetic acid in the treatment of ice-pick acne scar. Methods: Forty patients with ice-pick acne scar from outpatient unit department of dermatology in King Chulalongkorn Hospital were enrolled in this study. Fifty-percent trichloroacetic acid was used in the treatment of ice-pick acne scars on each patient's face every 3 weeks until week 24. Profilometry-Visioscan VC98 is used to quantify the degree of clinical improvement after the treatment. Qualitative assessment of clinical improvement was performed by each patient and two independent blinded physicians. Results: Only thirty-three patients out of forty patients were completed this study. A statistically significant improvement between the control and treatment groups was observed by evaluation from profilometry-Visioscan VC98 (p-value < 0.001). This finding agreed with the results assessed by each patient and two physicians. There was a statistically significant difference between the control and treatment groups based on these qualitative assessment results (p-value < 0.001). Transient erythema was founded in twenty-five patients (75.76%) and disappear within two weeks. Postinflammatory hyperpigmentation was observed in five patients (15.15%) but it resolved spontaneously within four weeks. Milia was found in only one patient (3.03%) after treatment at week 12. Conclusion: We conclude that fifty-percent trichloroacetic acid is a safe and effective method of treating ice-pick acne scars.