Title | DNA Repair in Cancer Therapy [electronic resource] / edited by Lawrence C. Panasci, Moulay A. Alaoui-Jamali |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 2004 |
Connect to | http://dx.doi.org/10.1007/978-1-59259-735-2 |
Descript | XI, 363 p. online resource |
Content -- 1 Clinical Resistance to Alkylators: Status and Perspective -- 2 Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking Agents -- 3 Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs -- 4 Chemosensitization to Platinum-Based Anticancer Drugs: Current Trends and Future Prospects -- 5 Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells -- 6 Stress-Activated Signal Transduction Pathways in DNA Damage Response: Implications for Repair, Arrest, and Therapeutic Interventions -- 7 Overcoming Resistance to Alkylating Agents by Inhibitors of O6-Alkylguanine-DNA Alkyltransferase -- 8 Cellular Protection Against the Antitumor Drug Bleomycin -- 9 Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death -- 10 Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy -- 11 Strand-Break Repair and Radiation Resistance -- 12 V(D)J Recombination and DNA Double-Strand-Break Repair: From Immune Deficiency to Tumorigenesis -- 13 Inherited Disorders of Genomic Instability and Cancer Susceptibility -- 14 Role of BRCA1 and BRCA2 in DNA Repair and Potential Impact on Therapeutics -- 15 Genetic Variations in DNA Repair: Their Implications in Human Cancer Risk, Prevention, and Therapy