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TitleInsulin Resistance [electronic resource] : The Metabolic Syndrome X / edited by Gerald M. Reaven, Ami Laws
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 1999
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Descript X, 374 p. online resource


In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Each author has been encouraged to present a point of view that reflects their unique insights. The first authoritative book on the subject, Insulin Resistance: The Metabolic Syndrome X illuminates the special importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome. Its thoughtful and detailed approach will make it an essential reference for basic and clinical researchers seeking to understand these critical phenomena


I Genetic and Environmental Factors Affecting Insulin Action -- 1 Genetics of Insulin Resistance -- 2 Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes -- 3 Fetal Effects on Insulin Resistance and Glucose Tolerance -- 4 Obesity and Insulin Resistance: Epidemiologic, Metabolic, and Molecular Aspects -- 5 The Role of Body Fat Distribution in Insulin Resistance -- 6 Physical Activity and Insulin Resistance in Man -- 7 Insulin Resistance in Smokers and Other Long-Term Users of Nicotine -- II Pathophysiology of Insulin Resistance -- 8 Insulin Resistance and Inhibitors of Insulin Receptor Tyrosine Kinase -- 9 NMR Studies on the Mechanism of Insulin Resistance -- 10 Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms -- 11 The Role of the Liver in Insulin Action and Resistance -- 12 The Pathophysiological Consequences of Adipose Tissue Insulin Resistance -- 13 Insulin Action and Endothelial Function -- III Clinical Syndromes Associated with Insulin Resistance -- 14 Insulin Resistance and Dyslipidemia: Implications for Coronary Heart Disease Risk -- 15 Insulin Resistance and Blood Pressure -- 16 Microalbuminuria and Insulin Resistance -- 17 PAI-1, Obesity, and Insulin Resistance -- 18 Insulin Resistance and Cardiovascular Disease -- 19 Insulin Resistance Effects on Sex Hormones and Ovulation in the Polycystic Ovary Syndrome

Medicine Endocrinology Medicine & Public Health Endocrinology


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