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TitleGastrointestinal Endocrinology [electronic resource] / edited by George H. Greeley
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 1999
Connect tohttp://dx.doi.org/10.1007/978-1-59259-695-9
Descript X, 585 p. online resource

SUMMARY

In Gastrointestinal Endocrinology, leading clinical and basic science researchers present the latest molecular and cellular findings on key gastrointestinal peptide hormones, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their actions in the gastrointestinal tract. The book focuses on gastrointestinal peptide hormone physiology, receptor biology and pharmacology, processing, and on regulatory mechanisms in the gut, including pancreatic feedback mechanisms. Also included are chapters on the trophic effects of gut peptides on GI and pancreatic cancer; the regulation of gut peptide gene expression; and gastric secretion, especially in disease states. Gastrointestinal Endocrinology offers authoritative, state-of-the-art chapters that address of the rapid progress which has occurred in elucidating the details of gastrointestinal endocrinology. The book will be indispensable to today's endocrinologists, gastroenterologists, surgeons, pharmacologists, and physiologists who want to better understand the regulatory role that peptides play in intercellular communication in the gut, as well as between the gut and other organs in the body


CONTENT

Structure and Function of Gastrointestinal Endocrine Cells -- 1 Biosynthesis and Processing of Gastrointestinal Peptide Hormones -- 2 Mechanisms That Attenuate Signaling by Regulatory Peptides -- 3 Cellular and Molecular Targets of Gastrin -- 4 Receptors for Peptides of the VIP/PACAP and PYY/NPY/PP Families -- 5 Cholecystokinin: Hormonal and Neurocrine Regulator of Postprandial Gastrointestinal Function -- 6 Effects of Aging on Gut Hormones -- 7 Gastrointestinal Hormones and Gastrointestinal Cancer Growth -- 8 Intraluminal Regulatory Peptides and Intestinal Cholecystokinin Secretion -- 9 Neuroendocrine Control of the Exocrine Pancreas -- 10 Neuroendocrine Immune Axis in the Intestine -- 11 Neuroendocrine Regulation of Intestinal Peristalsis -- 12 Pancreatic Polypeptide and Glucose Metabolism -- 13 Peptide Release from the Upper Small Intestine -- 14 Regulation of Gastric Acid Secretion -- 15 Role of Cholecystokinin in Physiologic and Pathophysiologic Growth of the Pancreas -- 16 Expression of the Neurotensin/Neuromedin N Gene in the Gut: A Potential Model for Gut Differentiation -- 17 Glucose-Dependent Insulinotropic Polypeptide (GIP): Incretin vs Enterogastrone -- 18 Insulin-Like Growth Factors and Their Receptors and Binding Proteins in the Gastrointestinal System -- 19 Intestinal Proglucagon-Derived Peptides -- 20 Islet Amyloid Polypeptide and Adrenomedullin: Novel Peptide Hormones Expressed in the Gastro-EnteroPancreatic Region -- 21 Peptide YY


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