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TitleAllergy and Allergic Diseases [electronic resource] : The New Mechanisms and Therapeutics / edited by Judah A. Denburg
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 1998
Connect tohttp://dx.doi.org/10.1007/978-1-4757-2776-0
Descript XVI, 599 p. online resource

SUMMARY

In Allergy and Allergic Diseases: The New Mechanisms and Therapeutics, a distinguished international panel of researchers and clinicians review the latest findings on the cellular and molecular foundations of allergic diseases, particularly those of the airway, skin, and bowel. The key topics treated span the range from epidemiology and the mechanisms of inflammation, to signaling in pathogenesis and allergic reactions. Each contributor treats the pathophysiology of allergy in various organ-based diseases and syndromes, emphasizing important new findings from cellular and molecular biology that illuminate these diseases, but also reveal important leads for the development of novel drugs and therapeutic strategies. Allergy and Allergic Diseases: The New Mechanisms and Therapeutics highlights the interface between basic and clinical science in allergic disease. Its up-to-date, clinically relevant approach constitutes the new standard knowledge base in clinical immunology and allergy, not only for specialists, but also for internists, for scientists studying the cellular and molecular biology of inflammation and immunity, and for researchers focused on drug discovery and therapeutics. Authoritative and timely, Allergy and Allergic Diseases is clearly the today's indispensable new resource for all physicians and investigators seeking a deeper understanding of allergy in both its basic and clinical aspects


CONTENT

I. Epidemiology/IgE -- 1 Molecular Mechanisms of Isotype Switching to IgE -- 2 Cytokines and IgE Regulation -- 3 Environmental Allergens -- 4 Ontogeny of Allergy -- II. Inflammation: Cellular Aspects -- 5 The Role of the Bone Marrow in Allergic Disease -- 6 The Role of Mast Cells in Inflammation and Homeostatis -- 7 Human Langerhans Cells -- 8 Eosinophils -- 9 Role of Basophils in Allergic Reactions -- 10 Neurogenic Inflammation in Allergic Disease -- 11 Inflammation: Thl/Th2 Cells -- 12 T-Cells in the Pathogenesis of Asthma and Allergic Diseases -- 13 Role of CD8+ T-Cells in the Regulation of Immunoglobulin E -- 14 Airway Wall Structure -- 15 Epithelium -- III. Inflammation: Molecular Aspects -- 16 Proinflammatory Cytokines in Allergic Disease -- 17 Hemopoietic Cytokines: Function, Receptors, and Signal Transduction -- 18 Adhesion Receptors in Allergic Disease -- 19 Cell/Cytokine Interactions -- 20 Signaling in Mast Cells -- 21 Signaling in Human Basophils -- 22 Eosinophil Signal Transduction -- IV. Pathogenesis -- 23 Pathogenesis of Allergic Rhinitis -- 24 Pathogenic Mechanisms of Urticaria -- 25 Atopic Eczema -- 26 Pathogenesis of Asthma -- 27 Pathogenesis of Allergic Conjunctivitis -- V. Therapeutics -- 28 Glucocorticoids (Corticosteroids) -- 29 Beta-Agonists -- 30 Sodium Cromoglycate and Nedocromil Sodium -- 31 Airway Remodeling and Repair


Medicine Allergy Medicine & Public Health Allergology



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