1 Membrane Transport -- 1. Introduction -- 2. General Aspects of Epithelial Organization Related to Nephron Function -- 3. Correlations between Function and Morphology in the Nephron -- 4. Isolation, Characterization, and Reconstitution of Membrane Transport Systems -- 5. Conclusions -- References -- 2 Renal Physiology: Renal Circulation, Glomerular Filtration, and Renal Handling of Sodium, Potassium, and Chloride -- 1. Renal Hemodynamics and Glomerular Filtration Rate -- 2. Renal Handling of Sodium Chloride -- 3. Potassium Transport -- References -- 3 Renal Metabolism -- 1. Introduction -- 2. Methodological Considerations -- 3. Biochemistry of the Glomerulus -- 4. Biochemistry of Tubular Membranes -- 5. Intermediary Metabolism and Regulation -- References -- 4 Renal Prostaglandins -- 1. Introduction -- 2. Prostaglandin Synthesis and Degradation -- 3. Prostaglandins, Sodium Excretion, and Diuretics -- 4. Prostaglandins, Vasopressin, and Water Excretion -- 5. Prostaglandins and Renin Release by the Kidney -- 6. Renal Blood Flow -- 7. Bartterโ{128}{153}s Syndrome -- 8. Ureteral Obstruction -- 9. Deleterious Clinical Effects of Nonsteroidal Antiinflammatory Drugs -- 10. Future Directions -- References -- 5 Acid-Base Physiology and Pathophysiology -- 1. Introduction -- 2. Proximal Tubular Acidification -- 3. Mechanism of Bicarbonate Reabsorption -- 4. Factors that Control Bicarbonate Reabsorption -- 5. Effect of Calcium on Urinary Acidification -- 6. Role of Vitamin D in Urinary Acidification -- 7. Effects of Pharmacological Agents on Bicarbonate Transport -- 8. Proximal Renal Tubular Acidosis -- 9. Hyperparathyroidism and Proximal Renal Tubular Acidosis -- 10. Distal Urinary Acidification -- 11. Studies in the Turtle Bladder -- 12. Effect of in Vivo Acid-Base Status on in Vitro Acidification -- 13. Metabolic Regulation of Urinary Acidification -- 14. Effect of Aldosterone on Urinary Acidification -- 15. Bicarbonate Exit -- 16. Role of Calcium, Magnesium, and Cyclic AMP in Acidification -- 17. Comparative Physiology of the Turtle Bladder and Mammalian Cortical Collecting Tubule -- 18. Distal Renal Tubular Acidosis Syndromes -- 19. Factors Responsible for Generation of a High Urinary CO2 Tension -- 20. Experimental Models of Distal Renal Tubular Acidosis -- 21. Human Distal Renal Tubular Acidosis -- 22. Role of Potassium Depletion in Acid-Base Homeostasis -- 23. Other Forms of Impaired Distal Acidification -- 24. Extrarenal Factors that Influence Acid-Base Homeostasis -- 25. The Role of the Gut in the Pathogenesis of the Hyperchloremic Acidosis of Ureterointestinal Anastomosis -- References -- 6 Mineral Metabolism in Health and Disease -- 1. Vitamin D -- 2. Parathyroid Hormone and Calcitonin -- 3. Calcium Physiology and Pathophysiology -- 4. Phosphate Physiology and Pathophysiology -- 5. Renal Osteodystrophy -- 6. Nephrolithiasis -- References -- 7 Hypertension and the Renin-Angiotensin-Aldosterone Axis -- 1. Introduction -- 2. Physiology and Pharmacology -- 3. Hypertension -- References -- 8 Immunologically Mediated Renal Disease -- 1. Introduction -- 2. Basic Investigations -- 3. Clinical Investigations -- References -- 9 Acute Renal Failure and Toxic Nephropathy -- 1. Introduction -- 2. Pathophysiological Considerations -- 3. Clinical Considerations -- 4. Summary and Conclusion -- References -- 10 The Kidney in Systemic Disease: Pathophysiological Schemes and Analysis of Two Diseases (Multiple Myeloma and Diabetes Mellitus) -- 1. Introduction -- 2. Reduction in Glomerular Filtration Rate in Systemic Illness -- 3. Alterations in Proximal-Tubular Function -- 4. Other Consequences of Proximal-Tubular Defects -- 5. Diminished Salt Transport in the Thick Ascending Limb of the Loop of Henle -- 6. Multiple Myeloma -- 7. Diabetes Mellitus -- References -- 11 Uremia -- 1. Introduction -- 2. Uremic Toxicity -- 3. Uremic Osteodystrophy -- 4. Cardiovascular Complications -- 5. Anemia -- 6. Disturbances of the Gastrointestinal Tract -- 7. Hormonal and Lipid Abnormalities -- 8. Immune Defects of Uremia -- 9. Psychological Impact of Renal Failure -- 10. Alternative Therapy of Uremia -- References -- 12 Nutrition in Renal Disease -- 1. Introduction -- 2. Nitrogen Metabolism -- 3. Glucose and Insulin Metabolism -- 4. Lipid Metabolism -- 5. Therapeutic Considerations -- 6. Chronic Renal Failure in Children -- 7. Acute Renal Failure -- References -- 13 Dialysis -- 1. Introduction -- 2. Overview -- 3. Vascular Access -- 4. Extracorporeal Devices -- 5. Peritoneal Dialysis -- 6. Problems and Complications of Dialysis -- 7. Removal of Drugs and Poisons by Dialysis or Hemoperfusion -- 8. Unusual Indications for Dialysis or Hemoperfusion -- References -- 14 Renal Transplantation -- 1. Clinical Transplantation -- 2. Clinical Immunology -- 3. Conclusion -- References -- 15 Drugs and the Kidney -- 1. Introduction -- 2. Basic Pharmacokinetics -- 3. Drug Handling by the Kidney -- 4. Clinical Use of Drugs in Renal Failure -- 5. Effects of Hemodialysis, Hemoperfusion, and Peritoneal Dialysis on Drug Pharmacokinetics -- References