Title | Male-Mediated Developmental Toxicity [electronic resource] / edited by Andrew F. Olshan, Donald R. Mattison |
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Imprint | Boston, MA : Springer US : Imprint: Springer, 1994 |
Connect to | http://dx.doi.org/10.1007/978-1-4615-1877-8 |
Descript | XII, 406 p. online resource |
Concepts and Mechanisms -- 1. Methods and Concepts in Detecting Abnormal Reproductive Outcomes of Paternal Origin -- Laboratory Evidence -- 2. Specific-Locus Mutation Tests in Germ Cells of the Mouse: An Assessment of the Screening Procedures and the Mutational Events Detected -- 3. Effects of Spermatogenic Cell Type on Quality of Mutations -- 4. Dominant Mutations in Mice -- 5. Aneuploidy Tests: Cytogenetic Analyses of Mammalian Male Germ Cells -- 6. Strategies for the Use of a Multiple-Endpoint System for Mammalian Germ Cell Mutation Testing -- 7. Transgenic Mice in Developmental Toxicology -- 8. Male Mice Receiving Very Low Doses of Ionizing Radiation Transmit an Embryonic Cell Proliferation Disadvantage to Their Progeny Embryos -- 9. Post-Testicular Mechanisms of Male-Mediated Developmental Toxicity -- Laboratory Evidence for Congenital Anomalies, Cancer and Neurobehavioral Outcomes -- 10. The Male-Mediated Developmental Toxicity of Cyclophosphamide -- 11. M ale-Mediated Teratogenesis: Ionizing Radiation/Ethylnitrosourea Studies -- 12. Preconception Exposure of Males and Neoplasia in Their Progeny: Effects of Metals and Consideration of Mechanisms -- 13. Male-Mediated Reproductive Toxicity: Effects on the Nervous System of Offspring -- Epidemiologic Findings -- 14. Paternal Occupation and Birth Defects -- 15. Male-Mediated Developmental Toxicity: Paternal Exposures and Childhood Cancer -- 16. Paternal Exposures and Pregnancy Outcome: Miscarriage, Stillbirth, Low Birth Weight, Preterm Delivery -- 17. Paternal Exposures and Embryonic or Fetal Loss: The Toxicologic and Epidemiologic Evidence -- 18. Reproductive Outcomes among Men Treated for Cancer -- 19. Genetic Effects of Atomic Bomb Exposure -- 20. Biological Factors Related to Male Mediated Reproductive and Developmental Toxicity -- 21. Antioxidant Prevention of Birth Defects and Cancer -- Risk Assessment and Policy Issues -- 22. Quantitative Risk Assessment for Paternally-Mediated Developmental Toxicity -- 23. Paternally-Mediated Developmental Toxicity: Implications for Risk Assessment and Science Policy -- 24. Physician and Patient Education -- 25. Characteristics of Male-Mediated Teratogenesis -- Abstracts -- 26. Aneuploidy Studies in Sperm: Post Meiotic Selection against Aneuploid Sperm -- 27. Association of Paternal and Maternal Exposure with Low Birth Weight and Preterm Births among Women Textile Workers -- 28. Genotoxic Consequences of Testicular Localization of Indium-114m -- 29. Male-Mediated Developmental and Reproductive Toxicity of Symm-Triazine Pesticides -- 30. National Transplantation Pregnancy Registry: Outcomes of Pregnancies Fathered by Male Transplant Recipients -- 31. Occupations of Fathers before Conception and the Risk of Testicular Cancer in Their Sons -- 32. Two-Dimensional Electrophoresis of Proteins: Detection and Characterization of Male-Mediated Developmental Toxicity -- Breakout Groups -- 33. Workshop Report on Mechanisms -- 34. Biomarkers and Health Endpoints of Developmental Toxicology of Paternal Origin: Summary of Working Group Discussions -- 35. Epidemiological Approaches -- 36. Laboratory Research Methods in Male-Mediated Toxicity -- 37. Physician and Patient Education -- 38. Risk Assessment and Risk Management -- 39. Multidisciplinary Approaches: Workshop Report -- Author Index