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TitlePathophysiology of Cardiovascular Disease [electronic resource] / edited by Naranjan S. Dhalla, Heinz Rupp, Aubie Angel, Grant N. Pierce
ImprintBoston, MA : Springer US : Imprint: Springer, 2004
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Descript XIX, 648 p. online resource


Pathophysiology of Cardiovascular Disease has been divided into four sections that focus on heart dysfunction and its associated characteristics (hypertrophy, cardiomyopathy and failure); vascular dysfunction and disease; ischemic heart disease; and novel therapeutic interventions. This volume is a compendium of different approaches to understanding cardiovascular disease and identifying the proteins, pathways and processes that impact it


1. Septic Cardiomyopathy -- 2. Mitochondrial Functionโ{128}{148}A Limiting Factor in Heart Failure? -- 3. Myosin Heavy Chain Isoforms Modulate Motor Function of Cardiac Myosin by Changing Crossbridge Kinetics -- 4. Role of Reactive Oxygen Species in the Regulation of Cardiac Myocyte Phenotype -- 5. Functional Significance of Ryanodine Receptor-Mediated Calcium Leaks in Sarcoplasmic Reticulum Membranes -- 6. Cell-Cell and Cell-Extracellular Matrix Interactions in Cardiomyopathy -- 7. Role of the Phosphoinositide 3-Kinase Pathway in Cardiac Hypertrophy -- 8. Role of Ras/GTPase and Calcium/Calmodulin-dependent Protein Kinase II in the Signal Transduction Mechanisms Involved in Hyperthermic Preconditioning -- 9. Interactions of the Cyclic AMP and Nitric Oxide Pathways in Cardiac Fibroblasts -- 10. Do Humoral and Mechanical Stimulation of Cardiomyocytes Share Common Transduction Pathways? -- 11. Differential Inhibition by the Phosphatase Inhibitor Cantharidin of the Antiadrenergic Effect of Endothelin-1 and Carbachol in the Canine Ventricular Myocardium -- 12. Factors Involved in Self and Drug-Induced Spontaneous Ventricular Defibrillation: Intra and Inter Species Variations -- 13. Cardiac ATP-Sensitive Potassium Channel: A Bi-Functional Channel/Enzyme Multimer -- 14. Measurement of Cytosolic pH Simultaneously with Isometric Tension in Canine Trabeculae -- 15. Redox Regulation of Ischemic Heart Disease -- 16. Cell Biology of Acute Reperfusion Injury -- 17. Reactive Oxygen Species, Na+/H+ Exchange and Ca2+ Overload During Myocardial Ischemia/Reperfusion Injury: The Paradox Explained? -- 18. Calcium Signalling During Acute Myocardial Ischemia: New Insights from Optical Mapping Techniques -- 19. Effects of Ischemia on Cardiomyocyte Connexin-43 Distribution and Phosphorylation Studied in in vivo and in vitro Models -- 20. Temperature Dependence of Ischemic Preconditioning -- 21. Mechanism of Cardioprotective Effect of Remote Aortic Preconditioning -- 22. Inhibition of Degranulation of Resident Cardiac Mast Cells May Prevent Ischaemia and Reperfusion-Induced Myocardial Injury -- 23. Mechanisms of Cardioprotection against Ischemia Reperfusion Injury -- 24. Modulation of Arachidonic Acid Metabolism by Phorbol 12-Myristate 13-Acetate in Monocytes and Myocytes -- 25. Endothelium-Derived Hyperpolarizing Factor(s). Does it exist and What Role Does it Play in the Regulation of Blood Flow? -- 26. Cytokinesis in Smooth Muscle -- 27. ADP-Ribosylation and the Cardiovascular System -- 28. Influence of the Myocardium Contractile State in the Coronary Venous Flow Deviation Phenomenon -- 29. Natriuretic Peptides and Endothelin in Aortic Stenosis and Heart Transplantation -- 30. Activation of Mitogen-Activated Protein Kinases and Protein Kinase B/Akt Signaling by Oxidative Stress in Vascular Smooth Muscle Cells: Involvement in Vascular Pathophysiology -- 31. Preconditioning and Myocardial Angiogenesis -- 32. The Arachidonic Acid Cascade: Thromboxane A2 Antagonism and Synthetase Inhibition in Experimental Myocardial Infarction -- 33. Receptors and Channels of Nuclear Envelope Membranes as a New Target for Drug Action -- 34. SMAD Cofactors/Corepressors in the Fibrosed Post-MI Heart: Possible Therapeutic Targets -- 35. Phytoestrogens and Cardiovascular Disorders -- 36. Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat -- 37. Fetal and Neonatal Cardiomyocyte Transplantation for the Treatment of Myocardial Infarction -- 38. Cellular Cardiomyoplasty: The Role of Bone Marrow Stromal Cells in Myocardial Tissue Regeneration -- 39. Xenotransplantation: An Overview -- 40. Assessment of Myocardial Injury Using Magnetic Resonance Imaging -- 41. Magnetic Resonance in the Assessment and Development of Surgical Strategies for Protecting the Brain during Cardiovascular Surgery -- 42. Heart Failure Recovery with Mechanical Circulatory Support

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