Author | Lancker, Julien L. Van. author |
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Title | Molecules, Cells, and Disease [electronic resource] : An Introduction to the Biology of Disease / by Julien L. Van Lancker |
Imprint | New York, NY : Springer New York, 1977 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-9418-1 |
Descript | 311 p. 28 illus. online resource |
1 The Concept of Disease and Its History -- Prehistoric Times -- Egypt, Greece, and Rome -- Medieval Times -- The Foundation of Modern Pathology -- Cellular Pathology -- The Origins of Chemical Pathology -- 2 Development of Existing Knowledge -- Gene Expression -- Cell Structure -- Intercellular Integration -- Conclusion -- 3 Defense Mechanisms -- First Line of Defense -- Blood Coagulation, Inflammation, and Immunity -- Restoration of Lost Tissues -- 4 Causes of Disease -- Hereditary Diseases -- Congenital Anomalies -- Conflict with the Environment -- Nutritional Deficiencies -- Hormonal Imbalances -- Body Fluids and Electrolyte Imbalances -- Defective Defense Mechanisms -- Excessive Response to Injury -- Conclusion -- 5 Injuries to Units of Specificity -- Primary Injury to DNA -- DNA Repair -- Consequences of Injuries to DNA -- Inherited Mutations -- Somatic Mutations -- Interference with DNA Synthesis -- Injuries to Transcription -- Pathology of Translation -- Conclusion -- 6 Injuries to Catalytic Units -- About Atoms and Molecules -- About Chemical Reactions -- About Enzyme Reactions -- Life Cycle of Enzymes -- Pathology of the Catalytic Unit -- Disease and Substrate Alteration -- Conclusion -- 7 Hormone Imbalance -- Endocrine Glands -- Mode of Action of Hormones -- Regulation of Hormone Secretion -- Second Messengers -- Hormone Degradation -- Hormonal Diseases -- 8 Pathology of Cell Membranes -- Function of the Plasma Membrane -- Structure of Cell Membranes -- Molecular Organization of the Cell Membrane -- Biosynthesis of the Cell Membrane -- The Cytocavitary Network -- Pathology of Cell Membranes -- Conclusion -- 9 Reflections on Cellular Death -- Primary, Secondary, and Critical Injuries -- Programmed Death -- Provoked Death -- Conclusion -- 10 The Great Killers, Atherosclerosis and Cancer -- Atherosclerosis -- Cancer -- 11 Aging -- Manifestations of Aging -- Possible Cellular Mechanisms in Aging -- Biological Causes of Aging -- Conclusion