Title | Biochemistry and Molecular Genetics of Cancer Metastasis [electronic resource] : Proceedings of the Symposium on Biochemistry and Molecular Genetics of Cancer Metastasis Bethesda, Maryland โ March 18-20, 1985 / edited by Karoly Lapis, Lance A. Liotta, Alan S. Rabson |
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Imprint | Boston, MA : Springer US, 1986 |
Connect to | http://dx.doi.org/10.1007/978-1-4613-2299-3 |
Descript | XVIII, 334 p. online resource |
One โ Biochemistry and Molecular Biology Aspects -- 1. Biochemical and molecular biology approaches to study cancer metastases -- 2. Use of the chick embryo in studying the molecular genetics of metastasis -- 3. Integral membrane adhesion glycoproteins: What is their fate during metastasis? -- 4. Peptide fragments of fibronectin and laminin: Role in cell adhesion and inhibition of experimental tumor metastasis -- 5. Role of ras oncogenes in experimental models of metastasis -- 6. Expression of p21ras gene products in fresh primary and metastatic human tumor tissue -- 7. A role for differentiation arrest in the development of neural crest tumors -- 8. Genetic and epigenetic regulation of the metastatic phenotype: A basis for resolving the controversy regarding its selective or random nature and variable phenotypic stability -- 9. Cytochemical cell typing of metastatic tumors according to their cytoskeletal proteins -- 10. Biochemistry and molecular biology RAW117 large cell lymphoma -- 11. Karyotypic progression and metastasis formation of human tumors -- 12. Morphological and functional alterations of occludens, adherens, and gap junctions in cancer -- 13. Pattern of basement membrane degradation by metastatic tumor cell enzymes -- Two โ Immunologic Mechanisms -- 14. Gene products of the major histocompatibility complex control the metastatic phenotype of tumor cells -- 15. Generation of metastatic cells via somatic cell fusion: A possible mechanism for tumor progression in-vivo -- 16. The recognition and destruction of metastatic cells by tumoricidal macrophages -- 17. Biological response modifiers for the therapy of metastases -- 18. Differences in cell surface characteristics of poorly and highly metastatic Lewis lung tumor variants -- 19. Characteristics of LL2 and its lectin-resistant not metastasizing variants -- 20. A role for cell surface sialic acid in liberating metastatic tumor cells from host control -- Three โ Clinical Perspectives and Applications -- 21. Tumor heterogeneity and empirical clinical cancer chemotherapy: Current status and future prospects -- 22. Hormonal regulation of metastases: Prospects for pharmacological manipulation -- 23. Use of anti-tumor MABs for diagnosis and immunotherapy of human tumors -- 24. New approaches to the adoptive immunotherapy of established metastatic cancer using lymphokine-activated killer cells and recombinant interleukin-2 -- 25. Preclinical screening of biological response modifiers: Application to the treatment of metastatic disease