|Title||Subcellular Basis of Contractile Failure [electronic resource] : Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11-13, 1989, Ottawa, Canada / edited by Borivoj Korecky, Naranjan S. Dhalla|
|Imprint||Boston, MA : Springer US, 1990|
|Descript||X, 332 p. online resource|
I. Role of Cations in Heart Function -- 1. Role for sodium channels and intracellular sodium in regulation of the cardiac force-frequency relation and contractility -- 2. Regulation of cardiac calcium current during suppression of second messenger intracellular enzymatic pathways -- 3. Hormonal and non-hormonal regulation of Ca2+ current and adenylate cyclase in cardiac cells -- 4. Calcium current in normal and hypertrophied isolated rat ventricular myocytes -- 5. Regulation of contractile activity in single adult cardiomyocytes isolated from four different species: The effect of reduced sodium gradient -- 6. Involvement of sodium-calcium exchange in cardiac pathology -- 7. Modifications in sarcolemmal regulation of Ca2+ with aging -- II. Cardiac Hypertrophy and Cardiomyopathies -- 8. Alterations of membrane proteins in cardiac hypertrophy -- 9. Signal transduction in myocardial hypertrophy and myosin expression -- 10. Molecular and subcellular mechanisms of thyroid hormone induced cardiac alterations -- 11. Membrane abnormalities and changes in cardiac cations due to alterations in thyroid status -- 12. Inhibitory effects of captopril on the onset of cardiomyopathy in cardiomyopathic hamsters -- 13. Altered myocardial contractility and energetics in renovascular hypertensive rats -- 14. Cardiac phosphatidylethanolamine N-methylation in normal and diabetic rats treated with L-propionylcarnitine -- III. Ischemic Heart Disease and Cardiac Failure -- 15. Dietary N-3 polyunsaturated fatty acids and ischemic heart disease -- 16. Role of free radicals in the development of ischemic heart disease -- 17. Cardiovascular membranes as models for the study of free radical injury -- 18. Oxidation of myofibrillar thiols: A mechanism of contractile dysfunction reversible by dithiothreitol -- 19. Cardiac contractile failure due to oxygen radicals in an ex vivo system -- 20. Subcellular basis of contractile failure in myocytes: Calcium overload or energy depletion?
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