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TitlePurines in Cellular Signaling [electronic resource] : Targets for New Drugs / edited by Kenneth A. Jacobson, John W. Daly, Vincent Manganiello
ImprintNew York, NY : Springer New York, 1990
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Descript XV, 448 p. online resource


Section 1: Adenosine Receptors and Effector Systems -- 1 Adenosine Agonists and Antagonists -- 2 Intracellular and Extracellular Metabolism of Adenosine and Adenine Nucleotides -- 3 Adenosine Deaminase and Adenosine Transport Systems in the CNS -- 4 Transport Systems for Adenosine in Mammalian Cell Membranes -- 5 Formation of Adenosine in the Heart from Extracellular Adenine Nucleotides -- 6 Central Nervous System Effects of Adenosine -- 7 Adenosine Receptor Sub-types in Isolated Tissues: Antagonist Studies -- 8 Molecular Probes for Adenosine Receptors -- 9 Purification of A1 Adenosine Receptor of Rat Brain Membranes by Affinity Chromatography -- 10 Characteristics of A1 Adenosine Receptors and Guanine Nucleotide Binding Proteins Co-Purified from Bovine Brain -- 11 Antagonist Radioligand Binding to Solubilized Porcine Atrial A1 Adenosine Receptors -- 12 Isolation of an Adenosine Binding Protein Which Has Properties Expected of the A1 Adenosine Receptor -- 13 Identification of the A2 Adenosine Receptor Binding Subunit by Photoaffinity Crosslinking -- 14 Human Placental Adenosine A2-Like Binding Sites Properties and Homology with Mammalian and Avian Stress Proteins -- 15 Cardiac Interstitial Fluid Adenosine in Normoxia and Hypoxia -- 16 Rationale for the Use of Adenosine in the Diagnosis and Treatment of Cardiac Arrhythmias -- 17 The Central Adenosine System as a Therapeutic Target in Stroke -- 18 Adenosine-Mediated Vasoconstriction in the Skin Microcirculation -- 19 Adenosine is an Antiinflammatory Autocoid: Adenosine Receptor Occupancy Promotes Neutrophil Chemotaxis and Inhibits Superoxide Anion Generation -- 20 Beta Adrenergic Receptor Mediated Stimulation of Adenine Nucleotide Catabolism and Purine Release in Human Adipocytes -- 21 Structure Activity Relationships for Adenosine Antagonists -- 22 Structure Activity Relationships for Adenosine Agonists -- 23 The Design of a Series of Highly A2 Selective Adenosine Agonists -- 24 Adenosine Agonists. Characterization of the N6-Subregion of the Adenosine A2 Receptor via Molecular Modeling Techniques -- 25 Physiological and Biochemical Aspects of โ{128}{156}Pโ{128}{157}-Site-Mediated Inhibition of Adenylyl Cyclase -- 26 Adenosine Receptors Mediating Inhibition of Peripheral and Central Neurons -- 27 Adenosine Receptors as Drug Targets: Fulfilling the Promise? -- 28 Mechanisms of Adenosine Action -- 29 Functional Roles of A1 and A2 Receptors in Rat Hippocampus and Striatum -- 30 Subclassification of Neuronal Adenosine Receptors -- 31 Effects of Adenosine on Mast Cells -- 32 The Role of Adenosine on the Gastric Acid Secretory Response -- 33 Adenosine Receptors and Signaling in the Kidney -- 34 Inhibition of the Function of Guanine Nucleotide Binding Proteins by the New Positive Inotropes -- 35 Blockade of Antigen Activated Signals by Xanthine Analogs in RBL-2H3 Cells:Evidence for a Novel Adenosine Receptor -- Section 2: Adenine Nucleotide Receptors and Effector Systems -- 36 Classification and Characterization of Purinoceptors -- 37 Structure Activity Relationships for Adenine Nucleotide Receptors on Mast Cells, Human Platelets, and Smooth Muscle -- 38 Modulation of Norepinephrine Release by ATP and Adenosine -- 39 The Phospholipase C Linked P2y-Purinergic Receptor -- 40 Roles of an ADP Receptor on the Platelet Surface in Mediating Aggregation and Fibrinogen Binding -- Section 3: Phosphodiesterase Enzymes and Inhibitors -- 41 Structural and Functional Characterization of Cyclic GMP-Stimulated Phosphodiesterases and Their Role in Intracellular Signal Transduction -- 42 Phosphodiesterase Genes from Flies to Mammals -- 43 Structure and Function of the High Affinity, Rolipram and RO 2-1724 Sensitive, cAMP Phosphodiesterases -- 44 Correlation of 3H-Rolipram Binding to a Cerebral cAMP Phosphodiesterase with Antidepressant Activity -- 45 Mechanism for Dual Regulation of the Particulate cGMP-Inhibited cAMP Phosphodiesterase in Rat Adipocytes by Isoproterenol and Insulin -- 46 Expression of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase in Developing and Adult Rat Brain -- 47 Regulation of cAMP Metabolism in PC12 Cells by Type II (cGMP-Activatable) Cyclic Nucleotide Phosphodiesterase -- 48 cGMP-Binding Phosphodiesterase: Novel Effects of cGMP Binding on the Interaction Between Functional Domains in the Enzyme -- 49 Clinical Investigations with Phosphodiesterase Inhibitors -- 50 Chemical Probes of Type IV Phosphodiesterase: Design, Synthesis, and Characterization of (3H)-2Y186126 as a Radioligand for Sites Within Cardiac Membranes -- 51 Purification of a cGMP-inhibited cAMP Phosphodiesterase from Vascular Smooth Muscle -- 52 Low KmcAMP Phosphodiesterase Isozymes and Modulation of Tone in Vascular, Airway and Gastrointestinal Smooth Muscle -- 53 Structure Activity Relationships of Xanthines as Inhibitors of Cyclic Nucleotide Phosphodiesterases and as Antagonists of Adenosine Receptors -- 54 Mechanisms of Xanthine Actions in Models of Asthma -- Section 4: Abstracts -- A Intracellular and Extracellular Metabolism of Adenosine and Adenine Nucleotides -- B Molecular Probes for Purinoceptors -- C Phosphodiesterases - Multiples Forms and Regulation -- D The Physiological Effects of Adenosine and Adenine Nucleotides -- E Structure Activity Relationships at Adenosine and ATP Receptors -- F Effector Systems for Modulation of Biological Response by Purines -- G Phosphodiesterase Inhibitors - Mechanisms and Structure Activity Relationships -- Author Index

Pharmacy Medicine Pharmacology Biochemistry Medicine & Public Health Medicine/Public Health general Biochemistry general Pharmacy Pharmacology/Toxicology


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