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AuthorBukowski, Ronald M. author
TitleBiology of Renal Cell Carcinoma [electronic resource] / by Ronald M. Bukowski, James H. Finke, Eric A. Klein
ImprintNew York, NY : Springer New York, 1995
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Descript XII, 275p. 40 illus. online resource


Biology of Renal Cell Carcinoma presents the proceedings of the Third International Symposium on the Biology of Renal Cell Carcinoma, March 1994. This symposium gathers "internationally acclaimed researchers from relevant fields of renal cell carcinoma to present their latest work and to interact on the interpretation of these findings and direction for subsequent studies. The program is directed to physicians and research scientists involved in the clinical and basic research aspects of the treatment of renal cell carcinoma." (from the Symposium Announcement) Topics covered in the areas of Molecular Biology of Renal Cell Carcinoma: Cytogenetics, Genetic Approaches to Therapy of Renal Cell Carcinoma, Immunology of Renal Cell Carcinoma - T-Cell Anergy, New Approaches with Renal Cell Carcinoma - Cytokines


I. Molecular Biology of Renal Cell Carcinoma -- 1 Classification of Renal Cell Carcinoma Based on Morphologic and Cytogenetic Correlations -- 2 Molecular Cytogenetic Stratification of Renal Cell Tumors -- 3 Oncogenes in Renal Cell Carcinoma -- 4 Molecular Studies of the VHL Tumor Suppressor Gene in Renal Cell Carcinoma -- 5 The Cloning of Tumor Suppressor Genes from the Short Arm of Human Chromosome 3 that Play a Role in the Development of Renal Cell Carcinoma -- 6 Expression of the Wilmsโ{128}{153} Tumor Suppressor Gene (WT1) in Renal Cell Carcinoma -- II Immunology of Renal Cell Carcinoma -- 7 Alterations in Signal Transduction in T Cells from Cancer Patients -- 8 Impaired Signal Transduction in Tumor Infiltrating T Cells from Patients with Renal Cell Carcinoma -- 9 Recruitment of MHC-Restricted Cytotoxic T Lymphocytes Specific for Renal Cell Carcinoma to the Tumor In Situ -- 10 T-Lymphocyte Response in Renal Cell Carcinoma -- 11 Adhesion Molecules in Renal Cell Carcinoma -- III Novel Therapeutic Approaches in Renal Cell Carcinoma -- A) Genetic Manipulation -- 12 Cellular and Molecular Considerations for the Treatment of Murine Renal Cancer -- 13 2-5A-Antisense: A Novel Approach to Cancer Therapy -- 14 Analysis of Immune Response Induced by Tumors Engineered to Secrete Cytokines -- 15 New Avenues of Cancer Treatment: Modulation of Host Antitumor Directed Immune Responses by IL-4 and IL-12 in Renal Cell Cancer -- B) Cytokines/Adoptive Immunotherapy -- 16 Interleukin 12: Biology and Preclinical Studies of a New Anti-Tumor Cytokine -- 17 Cytokine Therapy of Metastatic Renal Cell Carcinoma: The Cleveland Clinic Experience -- 18 The Use of Cytokines, Tumor Infiltrating Lymphocytes, and Gene Therapy in the Treatment of Advanced Renal Cell Carcinoma: The UCLA Experience -- 19 Inhalational Interleukin-2 in the Treatment of Pulmonary Metastases in Patients with Renal Cell Carcinoma -- 20 Combination Immunotherapy with Interleukin-2 (IL-2), Alpha-Interferon (?IFN), and Autologous IL-2-Activated Lymphocytes (LAK) in Metastatic Renal Cell Cancer -- 21 T Cell Therapy of Patients with Advanced Renal Cell Carcinoma -- 22 Adoptive Immunotherapy with Interleukin-2 and LAK Cells or Gene Modified TIL in Patients with Renal Cell Carcinoma: Clinical and Laboratory Data -- C) Monoclonal Antibodies -- 23 Antibody Localization in Human Renal Cell Carcinoma: A Phase 1 Study of Monoclonal Antibody G250

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