Title | Bone Metastases [electronic resource] : Diagnosis and Treatment / edited by R. D. Rubens, I. Fogelman |
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Imprint | London : Springer London, 1991 |
Connect to | http://dx.doi.org/10.1007/978-1-4471-3254-7 |
Descript | XII, 247 p. online resource |
1 The Nature of Metastatic Bone Disease -- Biology of Bone Metastases -- Patterns of Bone Metastases -- Morbidity from Bone Metastases -- Assessment of Skeletal Disease -- 2 Normal Bone Remodelling and Its Disruption in Metastatic Bone Disease -- Normal Bone Structure -- Normal Bone Modelling -- Normal Bone Remodelling -- Regulation of Bone Remodelling -- Effects of Tumours on Bone -- Osteosclerosis -- Effects of Some Specific Tumour Cell Types in Bone -- Summary -- 3 The Bone Scan in Metastatic Disease -- Pathophysiology of Skeletal Uptake of Diphosphonate -- Bone Scan Imaging -- Breast Cancer -- Prostatic Cancer -- Other Genito-urinary Tract Tumours -- Lung Cancer -- Neuroblastoma -- Other Tumours -- 4 Radiology -- Skeletal Survey -- Distribution and Routes of Spread -- Radiographic Appearances -- Computed Tomography -- Radiological Appearances at Specific Sites -- Radiological Appearance of Specific Metastases -- Comparison of Skeletal Survey and Isotope BoneScans -- Response to Treatment -- Summary -- 5 Magnetic Resonance Imaging -- Principles of Magnetic Resonance Imaging -- Technical Considerations -- MRI of Normal Bone Marrow -- MRI of Pathological Bone Marrow -- Comparison of Malignant and Osteoporotic Vertebral Collapse -- Patterns of Vertebral Metastases -- Sensitivity of MRI -- Spinal Cord Compression -- Monitoring Response to Treatment -- Conclusions -- 6 Assessment of Response to Treatment -- Imaging of Bone Metastases -- Biochemical Monitoring -- Subjective Assessment -- Tumour Markers -- Suggestions for Future Study -- 7 The Systemic Treatment of Bone Metastases -- Systemic Therapy -- Direct Anti-tumour Therapy -- Inhibitors of Tumour Effects on Host Cells -- Conclusions and Prospects -- 8 Pathogenesis and Management of Cancer-Associated Hypercalcaemia -- Pathogenesis of Cancer-Associated Hypercalcaemia -- Classification -- Mediators of Hypercalcaemia -- Mechanisms of Hypercalcaemia: Summary -- Management of Cancer-Associated Hypercalcaemia -- Clinical Assessment -- Indications for Treatment -- Principles of Medical Management -- Specific Management Problems -- 9 Radiotherapy in the Management of Bone Metastases -- Principles of External Beam Irradiation -- Radiotherapy Treatment Techniques for Bone Metastases -- Biological Effects of Ionising Radiation -- Pathological Changes after Bone Irradiation -- Clinical Use of Radiotherapy for Bone Metastases -- Conclusion -- 10 Isotope Therapy for Bone Metastases -- Characteristics of Radionuclides Used for Therapy -- The Criteria for Selection -- Mechanisms for Localisation -- The Use of Radionuclides for Therapy -- Radiopharmaceuticals for Therapy -- Monoclonal Antibodies -- Radionuclide Therapy for Bone Metastases: Current Status -- The Future -- 11 The Role of the Orthopaedic Surgeon in the Treatment of Skeletal Metastases -- Impending Fractures -- Pathological Fractures -- Non-pathological Fracture in a Patient with Malignant Disease -- Spinal Instability -- Compression of the Spinal Cord or Cauda Equina -- Non-metastatic Orthopaedic Conditions in Patients with Malignant Disease -- 12 Symptomatic and Supportive Care -- The Use of Drugs to Control Pain from Bone Metastases -- Orthopaedic Surgical Treatment -- Radiotherapy -- Transcutaneous Nerve Stimulation -- Acupuncture -- Intercostal Nerve Block -- Paravertebral Block -- Dorsal Root Ganglion Rhizolysis -- Percutaneous Cervical Cordotomy -- Pituitary Alcohol Injection -- The Place of the Support Team -- Conclusion