Author | Ewens, Warren J. author |
---|---|
Title | Mathematical Population Genetics [electronic resource] : I. Theoretical Introduction / by Warren J. Ewens |
Imprint | New York, NY : Springer New York : Imprint: Springer, 2004 |
Edition | Second Edition |
Connect to | http://dx.doi.org/10.1007/978-0-387-21822-9 |
Descript | XX, 418 p. online resource |
1 Historical Background -- 1.1 Biometricians, Saltationists and Mendelians -- 1.2 The Hardy-Weinberg Law -- 1.3 The Correlation Between Relatives -- 1.4 Evolution -- 1.5 Evolved Genetic Phenomena -- 1.6 Modelling -- 1.7 Overall Evolutionary Theories -- 2 Technicalities and Generalizations -- 2.1 Introduction -- 2.2 Random Union of Gametes -- 2.3 Dioecious Populations -- 2.4 Multiple Alleles -- 2.5 Frequency-Dependent Selection -- 2.6 Fertility Selection -- 2.7 Continuous-Time Models -- 2.8 Non-Random-Mating Populations -- 2.9 The Fundamental Theorem of Natural Selection -- 2.10 Two Loci -- 2.11 Genetic Loads -- 2.12 Finite Markov Chains -- 3 Discrete Stochastic Models -- 3.1 Introduction -- 3.2 Wright-Fisher Model: Two Alleles -- 3.3 The Cannings (Exchangeable) Model: Two Alleles -- 3.4 Moran Models: Two Alleles -- 3.5 K-Allele Wright-Fisher Models -- 3.6 Infinitely Many Alleles Models -- 3.7 The Effective Population Size -- 3.8 Frequency-Dependent Selection -- 3.9 Two Loci -- 4 Diffusion Theory -- 4.1 Introduction -- 4.2 The Forward and Backward Kolmogorov Equations -- 4.3 Fixation Probabilities -- 4.4 Absorption Time Properties -- 4.5 The Stationary Distribution -- 4.6 Conditional Processes -- 4.7 Diffusion Theory -- 4.8 Multi-dimensional Processes -- 4.9 Time Reversibility -- 4.10 Expectations of Functions of Diffusion Variables -- 5 Applications of Diffusion Theory -- 5.1 Introduction -- 5.2 No Selection or Mutation -- 5.3 Selection -- 5.4 Selection: Absorption Time Properties -- 5.5 One-Way Mutation -- 5.6 Two-Way Mutation -- 5.7 Diffusion Approximations and Boundary Conditions -- 5.8 Random Environments -- 5.9 Time-Reversal and Age Properties -- 5.10 Multi-Allele Diffusion Processes -- 6 Two Loci -- 6.1 Introduction -- 6.2 Evolutionary Properties of Mean Fitness -- 6.3 Equilibrium Points -- 6.4 Special Models -- 6.5 Modifier Theory -- 6.6 Two-Locus Diffusion Processes -- 6.7 Associative Overdominance and Hitchhiking -- 6.8 The Evolutionary Advantage of Recombination -- 6.9 Summary -- 7 Many Loci -- 7.1 Introduction -- 7.2 Notation -- 7.3 The Random Mating Case -- 7.4 Non-Random Mating -- 7.5 The Correlation Between Relatives -- 7.6 Summary -- 8 Further Considerations -- 8.1 Introduction -- 8.2 What is Fitness? -- 8.3 Sex Ratio -- 8.4 Geographical Structure -- 8.5 Age Structure -- 8.6 Ecological Considerations -- 8.7 Sociobiology -- 9 Molecular Population Genetics: Introduction -- 9.1 Introduction -- 9.2 Technical Comments -- 9.3 Infinitely Many Alleles Models: Population Properties. -- 9.4 Infinitely Many Sites Models: Population Properties -- 9.5 Sample Properties of Infinitely Many Alleles Models. -- 9.6 Sample Properties of Infinitely Many Sites Models -- 9.7 Relation Between Infinitely Many Alleles and Infinitely Many Sites Models -- 9.8 Genetic Variation Within and Between Populations -- 9.9 Age-Ordered Alleles: Frequencies and Ages -- 10 Looking Backward in Time: The Coalescent -- 10.1 Introduction -- 10.2 Competing Poisson and Geometric Processes -- 10.3 The Coalescent Process -- 10.4 The Coalescent and Its Relation to Evolutionary Genetic Models -- 10.5 Coalescent Calculations: Wright-Fisher Models -- 10.6 Coalescent Calculations: Exact Moran Model Results -- 10.7 General Comments -- 10.8 The Coalescent and Human Genetics -- 11 Looking Backward: Testing the Neutral Theory -- 11.1 Introduction -- 11.2 Testing in the Infinitely Many Alleles Models -- 11.3 Testing in the Infinitely Many Sites Models -- 12 Looking Backward in Time: Population and Species Comparisons -- 12.1 Introduction -- 12.2 Various Evolutionary Models -- 12.3 Some Implications -- 12.4 Statistical Procedures -- Appendix A: Eigenvalue Calculations -- References -- Author Index