This independent study is to develop a strategic marketing plan for Silom Health Care drug store with objectives of increasing sale volume and net profit. Target markets are existing customers with a positioning of top of heart drugstore in Silom area having many kind of healthcare product serving by pharmacist all day. The competitive strategy is market penetration and market development. Product strategy is to extend product lines especially food supplements and vitamins along with efficient customer services. Pricing strategy will focus on competitive pricing strategy which can compete against competitor in the same area. Distribution strategy will use renovate plan from the traditional drugstore style to be more modern. Integrated marketing communications strategy is to use sale promotion and give free sample to customer to build brand awareness. Total marketing budget is 620,000 Baht with an expected profit increasing 25%