The objective of this research is to investigate adsorption efficiencies of lignin, tannin, humic and fulvic acids by surface and structure modified mesoporous silicates such as titanium and aluminum substituted mesoporous silicate and functionalization with 3-aminopropyltriethoxy- 3-mercaptopropyl- and n-octyldimethyl- groups. Moreover, powdered activated carbon (PAC) and Fe3O4 particle were included in this study. Kinetic and isotherm adsorption were performed at high concentration (0-400mg/L) in this study to determine adsorption rate and adsorption capacity. Effect of pH on adsorption capacity and selective adsorption of ciprofloxacin (CIP) in the presence of humic were also studied. The obtained results indicated that 3-aminopropyltriethoxy- group grafted on mesoporous silicates performed highest adsorption capacity of lignin and humic while PAC provided highest adsorption capacity for tanin and fulvic acid. The adsorption capacities of these compounds are strongly relate to interaction caused by surface hydrophobicity and electrostatic charge between adsorbents and adsorbates. Moreover, the enhancement of CIP adsorption by co-existing humic is likely because CIP may directly interact with humic to form complex compounds which become a larger molecule and more available active sites for adsorption, leading to enhanced CIP adsorption.