The frontispiece, Leonardo da Vinci's drawing of the embryo in the womb, was chosen as a starting point for this book. It was Leonardo who in his notebooks and drawings combined artistic composition and accurate recording of the anatomy of the human body. Leonardo studied human anatomy in order to execute artistic drawings. His aim was to clarify form and function of human organs including reproductive organs. He followed up his extensive research with graphic representaยญ tion and thereby initiated record keeping as a basis of scientific investigation. His records, accurate three-dimensional drawings, allowed others to reproduce his findยญ ings and to test for correctness. Results could be updated and refined. Only after these steps can abnormalities be ascertained and defined as pathology. Though Leonardo was both artist and scientist, it is assumed that his anatomic drawings were used to improve his art, and thus scientific endeavor was at the service of his art. Anatomy, the offspring of science and art, is an integration of the two and became an accepted branch of the natural sciences. Although art and science continued to interact throughout the Renaissance, art was often placed in the service of science. In the course of history that followed, art and science inยญ creasingly followed separate ways
CONTENT
1. Ultrastructure and Calcium Stores in the Myometrium -- 2. Uterine Metabolism and Energetics -- 3. Myosin Light Chain Phosphorylation in Uterine Smooth Muscle -- 4. Thin Filament Control of Uterine Smooth Muscle -- 5. Calcium Control Mechanisms in the Myometrial Cell and the Role of the Phosphoinositide Cycle -- 6. Calcium Channels: Role in Myometrial Contractility and Pharmacological Applications of Calcium Entry Blockers -- 7. The Role of Membrane Potential in the Control of Uterine Motility -- 8. ?-Adrenoceptors, Cyclic AMP, and Cyclic GMP in Control of Uterine Motility -- 9. Physiological Roles of Gap Junctional Communication in Reproduction -- 10. Molecular Mechanisms of Steroid Hormone Action in the Uterus -- 11. Oxytocin in the Initiation of Labor -- 12. Oxytocin Receptors in the Uteru -- 13. Regulatory Peptides and Uterine Function -- 14. Biosynthesis and Function of Eicosanoids in the Uterus -- 15. Pharmacological Application of Prostaglandins, Their Analogues, and Their Inhibitors in Obstetrics -- 16. Fetal Tissues and Autacoid Biosynthesis in Relation to the Initiation of Parturition and Implantation -- 17. Endocrinology of Pregnancy and Parturition -- 18. Circulation in the Pregnant Uterus -- 19. Effects of Obstetric Analgesia and Anesthesia on Uterine Activity and Uteroplacental Blood Flow
