การศึกษาความสัมพันธ์ระหว่างความหลากหลายของสารพันธุกรรมอะโปไลโปโปรตีนอีและการเกิดโรคไตในผู้ป่วยเบาหวานชนิดที่สอง / สุวิมล เจียรักสุวรรณ = Association between apolipoprotein E polymorphism and the development of diabetic nephropathy in type 2 diabetic patients / Suwimol Jearraksuwan
Background: Apolipoprotein E (ApoE) genetic polymorphism has been proposed as a risk factor in the development of diabetic nephropathy. The aim of this study was to investigate the association between ApoE polymorphism and the development of diabetic nephropathy in type 2 diabetic patients. Method: A cross-sectional case control study included 126 Thai subjects with type 2 diabetes. The subjects who had duration of diabetes at least 10 years with normoalbuminuria and normal renal function (serum creatinine up to 1.2 mg/dl) assigned as a control group(n = 63). A case group composed of the type 2 diabetic subjects who had microalbuminuria (n = 63). ApoE genotypes and allelic distributions were determined by base sequencing. Results: Subjects with microalbuminuria had significantly higher body mass index, systolic blood pressure, HbA1c, serum creatinine and triglyceride levels than normoalbuminuria group. ApoE genotypes and allelic frequencies of e2, e3 or e4 were not significantly different between normoalbuminuria group and microalbuminuria group. Conclusions: We concluded that the ApoE polymorphism may not associate with microalbuminuria in type 2 diabetic patients.
