ประสิทธิผลของแผ่นยาชาลิโดเคนที่ผลิตขึ้นเองในประเทศเปรียบเทียบกับเบนโซเคนเจล 20% ในการลดความเจ็บปวดจาการแทงเข็มฉีดยา / พรทิพย์ จุฑาชวกุล = The efficacy of the locally made intraoral lidocaine patch compared with 20% benzocaine gel in reducing pain caused by needle injection / Porntip Chutachavakul
The objectives of this study were to determine the anesthetic onset and duration of locally made intraoral patch and to evaluate the efficacy of this patch compared with benzocaine gel in reducing pain caused by needle injection. Thirty healthy participants, aged 20 to 58 years, who were screened by rating VPS≥2 or VAS≥30 to placebo (no medication) patches, were recruited into the study. The onset and anesthetic duration of the lidocaine patch were determined on buccal and palatal sides of premolar regions. On buccal side, each participant received needle insertion with and without contacting periosteum, whereas on palatal side the participants received needle insertion only 2-3 mm depth of the mucosa without periosteum contact. Pain was evaluated by VPS and VAS just before lidocaine patch placement and immediately after each insertion. The onset of the lidocaine patch was then calculated and used for comparing the efficacy with benzocaine gel. The results showed that on buccal side the onset of the lidocaine patch were 15 and 1 minutes for needle insertion with and without periosteum contact respectively. The anesthetic duration lasted no longer than 15 minutes after removal of the patch either with or without periosteum contact. On palatal side, the onset of the lidocaine patch was 10 minutes and the duration was least 30 minutes after removal of the patch. The efficacy of the patches and benzocaine get for needle insertion without periosteum contact were compared using the mean pain scores. On buccal side the VPS and VAS scores were 0.30±0.54 and 4.00±6.30 respectively for the lidocaine patch, which showed statistically significant difference from those of benzocaine gel [0.90±0.85 (VPS) and 14.00±17.76 (VAS)](p=0.002). On palatal side, the mean pain scores of the lidocaine patch were 0.83±0.46 and 11.08±9.75 respectively, which showed no statistically difference from those of benzocaing gel [1.03±0.56 (VPS) and 14.10±12.43 (VAS)]. This study revealed the superior efficacy of the locally made intraoral lidocaine patch in reducing pain caused by needle injection on buccal side when comparing with benzocaine gel.