This experimental study evaluates the effectiveness of constraint-induced movement technique (CIMT) for 2 weeks in the dexterity with Action Research Arm Test (ARA test), activities of daily living with Functional Independent Measure (FIM), hand grip strength, pinch strength with grip and pinch dynamometer and spasticity with Modified Ashworth Scale (MAS) of affected upper extremities in chronic stroke patients. In an observer-blinded randomized control trail, 69 chronic stroke patients were allocated to either constraint-induced movement technique (n=33) or only conservative treatment (n=36). The CIMT group receieved 6 hours of daily affected upper extremities training and restrained unaffected upper extremities for 5 days per weeks, totally 2 weeks. The control group received only upper extremities training without restrained unaffected upper extremities for 2 weeks. The results of this study showed that the CIMT group has ARA test, FIM, pinch strength of affected upper extremities statistically significant higher than the control group and significant lower spasticity of affected upper extremities than the control group at p < 0.05 but hand grip strength was no statistically significant difference at p > 0.05. Therefore, constraint-induced movement technique of unaffected upper extremities is advantage for chronic stroke patients. This study may be an efficacious technique of improving motor activity and use of the affected side of patients exhibiting learned nonuse.