Microbiological perspectives in the twenty-first century / William Wade -- Diagnosis, epidemiology, and global impact of endodontic infections / Dag ¢rstavik -- Microbiology of caries and dentinal tubule infection / Robert M. Love -- Culture-based analysis of endodontic infections / Gunnar Dahl{acute}en -- Molecular analysis of endodontic infections / Jos{acute}e F. Siqueira, Jr., and Isabella N. R{circ}o{cedil}cas -- Extraradicular endodontic infections / Leif Tronstad -- Virulence of endodontic bacterial pathogens / Christine M. Sedgley -- Herpesviruses in endodontic pathosis / Mohammad Sabeti -- Fungi in endodontic infections / Bilge Hakan Sen and B. G{uml}uniz Baksi -- Management of aggressive head and neck infections / Domenick P. Coletti and Robert A. Ord -- Endodontic infections and pain / Anibal Diogenes and Ken M. Hargreaves -- Systemic antibiotics in endodontic infections / J. Craig Baumgartner and John R. Smith -- Topical antimicrobials in endodontic therapy / Tuomas Waltimo and Matthias Zehnder -- Endodontic infections in incompletely developed teeth / George T.-J. Huang -- Prognosis of treatment of teeth with endodontic infections / Shimon Friedman -- Endodontic infections and systemic disease / Ashraf F. Fouad