Title | Predictive Biomarkers in Oncology [electronic resource] : Applications in Precision Medicine / edited by Sunil Badve, George Louis Kumar |
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Imprint | Cham : Springer International Publishing : Imprint: Springer, 2019 |
Edition | 1st ed. 2019 |
Connect to | https://doi.org/10.1007/978-3-319-95228-4 |
Descript | XXI, 642 p. 156 illus., 153 illus. in color. online resource |
Introduction to Predictive Biomarkers: definitions and characteristics -- Introduction to clinical trials, clinical trial designs and statistical terminology used for predictive biomarker research and validation -- Overview of Methods Used in Predictive Biomarker Studies in a Molecular Anatomic Pathology Laboratory -- Significance of Immunohistochemistry and In Situ Hybridization Techniques for Predictive Biomarker Studies -- Overview of PCR-based Technologies and Multiplexed Gene Analysis for Biomarker Studies -- Introduction to Microarray Technology -- Digital and Computational Pathology for Biomarker Discovery -- Detection of Predictive Biomarkers Using Liquid Biopsies -- Measurement of Predictive Cancer Biomarkers by Flow Cytometry -- Personalized Cancer Treatment and Patient Stratification Using Massive Parallel Sequencing (MPS) and Other OMICs Data -- Bioinformatic Methods and Resources for Biomarker Discovery, Validation, Development, and Integration -- Overview of Cell Signaling Pathways in Cancer -- Steroid Hormone and Nuclear Receptor signaling pathways -- Protein kinase C Signaling in Carcinogenesis -- Roles of Rho/ROCK in Cancer Signaling -- Mitogen Activated Protein Kinase (MAPK) Signaling -- Notch Signaling Pathway in Carcinogenesis -- Signaling of the ErbB receptor Family in Carcinogenesis and the Development of Targeted Therapies -- Signaling Pathways in Tumor Angiogenesis and Anti-angiogenic Therapies in Human Cancer -- Role of PI3K/AKT/mTOR in Cancer Signaling -- Met Signaling in Carcinogenesis -- Role of Insulin-like Growth Factor Receptors in Cancer Signaling -- Role of Wnt/β-catenin Pathway in Cancer Signaling -- Hedgehog Signaling in Carcinogenesis -- TGF-β and the SMAD Signaling Pathway in Carcinogenesis -- Role of JAK-STAT Pathway in Cancer Signaling -- NF-kB signaling pathways in Carcinogenesis -- Immune-Signaling in Carcinogenesis -- Predictive Biomarkers and Targeted Therapies in Immuno-Oncology -- Role of Protein Tyrosine Phosphatases in Cancer Signaling -- Predictive and Prognostic Biomarkers in Myeloid Neoplasms -- Predictive Biomarkers and Targeted Therapies for Lymphoid Malignancies -- Targeted Therapies for Pediatric Central Nervous System Tumors -- Predictive Biomarkers and Targeted Therapies in Adult Brain Cancers -- Predictive Biomarkers and Targeted Therapies in Breast Cancer -- Predictive Biomarkers in Lung Cancer -- Predictive Biomarkers and Targeted Therapies in Genitourinary Cancers -- Predictive Biomarkers and Targeted Therapies in Colorectal Cancer -- Predictive Markers and Targeted Therapies in Gastroesophageal Cancer (GEC) -- Predictive Biomarkers and Targeted Therapies in Hepatic, Pancreatic, and Biliary Cancers -- Gynecological Cancers & Head and Neck Cancers -- Predictive Biomarkers and Targeted Therapies in Head and Neck Cancer -- Predictive Biomarkers and Targeted Therapies in the Skin -- Predictive Biomarkers and Targeted Therapies in Sarcomas -- Predictive Markers and Targeted Therapies in Thyroid Cancer and Selected Endocrine Tumors -- The Response Evaluation Criteria in Solid Tumors (RECIST) -- IVDs and FDA Marketing Authorizations: A General Overview of FDA Approval Process of an IVD Companion Diagnostic Device in Oncology -- Quality Control of Immunohistochemical and In Situ hybridization Predictive Biomarkers for Patient Treatment: Experience from International Guidelines and International Quality Control Schemes -- Use of Companion Diagnostics (CDx) and Predictive Biomarkers for Cancer Targeted Therapy. Clinical Applications in Precision Medicine -- Policy issues in the clinical development and use of predictive biomarkers for molecular targeted therapies -- Role of central laboratories in research, validation and application of predictive biomarkers -- Prominent Precision Medicine Clinical Trials in Oncology Around the World -- Precision Medicine Clinical Trials: Successes and Disappointments, Challenges and Opportunities. Lessons Learnt -- FDA Approved Targeted Therapies in Oncology