Title | Diabetic Nephropathy [electronic resource] : Pathophysiology and Clinical Aspects / edited by Joris J. Roelofs, Liffert Vogt |
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Imprint | Cham : Springer International Publishing : Imprint: Springer, 2019 |
Edition | 1st ed. 2019 |
Connect to | https://doi.org/10.1007/978-3-319-93521-8 |
Descript | XVI, 548 p. 81 illus., 67 illus. in color. online resource |
1. Diabetic nephropathy – Scope of the problem -- Historical overview of diabetic kidney disease -- Clinical features and natural course of diabetic nephropathy -- Global, regional and ethnic differences in diabetic nephropathy -- Diabetic nephropathy in children and adolescents -- Renal disease in obesity, metabolic syndrome and diabesity -- 2. Pathophysiology and clinical pathology of the diabetic kidney -- Introduction to pathogenetic mechanisms of diabetic nephropathy -- The genetics of diabetic nephropathy -- Pathology of the kidney in diabetes -- 3. The glomerulus -- The mesangial cell in diabetic nephropathy -- The glomerular endothelium in diabetic nephropathy - role of heparanase -- The podocyte in diabetic nephropathy: recent advances -- Inflammatory processes in diabetic glomeruli -- 4. The tubulointerstitium -- Proteinuria and tubulotoxicity -- Tubulo-glomerular communication in diabetic nephropathy -- Mechanisms of interstitial fibrosis in diabetic nephropathy -- 5. Microvascular involvement -- Microvascular damage and hemodynamic alterations in diabetic nephropathy -- Coagulation and hemostasis in diabetic nephropathy -- Renal hemodynamics in diabetic kidney disease - relevance for intervention -- Microvascular complications in the eye: diabetic retinopathy -- 6. Macrovascular involvement -- Hypertension in diabetic kidney disease -- Macrovascular involvement in diabetes - renal artery stenosis -- Atherosclerosis and diabetic nephropathy -- 7. Experimental designs -- Animal models of diabetic kidney disease -- Clinical trial and error in diabetic nephropathy -- 8. Therapy of diabetic nephropathy -- Treatment goals in diabetic nephropathy -- Kidney transplantation and diabetic nephropathy -- 9. Future developments -- Health programs in low- and middle-income countries -- OMICs in diabetic kidney disease -- Future and novel compounds in the treatment of diabetic nephropathy