Furofuran lignans are well known to possess broad range biological activities, particularly antioxidant. However, to date the structure-activity relationship has not been studied owing to the lack of a practical synthetic route for producing diverse furofuran lignans. Herein, we investigated a single-step synthesis of furofuran lignans starting from samin. This synthetic strategy involved the C-C bond formation between samin and electron-rich phenolics under acidic condition to generate the target products in good yields.Moreover, this synthetic strategy was applied to the synthesis of new flavanolignan, which was prepared from samin and chalcone flavonoid.