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TitleThermodynamics and kinetics of drug binding
Author edited by Gyorgy M. Keseru and David C. Swinney
ImprintWeinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, [2015]
Descript xxiii, 334 pages : illustrations (some color) ; 25 cm


Thermodynamics: The binding thermodynamics of drug candidates -- van't Hoff based thermodynamics -- Computation of drug-binding thermodynamics -- Thermodynamics-guided optimizations im medinal chemistry -- From molecular understanding to structure -thermodynamic relationships, the case of acetylcholone binding proteins -- Thermodynamics in lead optimization -- Thermodynamic profiling of carbonic anhydrase inhibitors -- Kinetics: Drug-target residence time -- Experimental methods to determine binding kinetics -- Challenges in the medicinal chemical optimization of binding kinetics -- Computational approaches for studying drug binding kinetics -- The use of structural information to understand binding kinetics -- Importance of drug-target residence time at G protein-coupled receptors -- a case for the adenosine receptors -- Case study: angiotensin receptor blockers (ARBs) -- The kinetics and thermodynamics of staphylococcus aureus Fable inhibition -- Perspective: Thermodynamics and binding kinetics in drug discovery

Drug development Binding sites (Biochemistry) -- Thermodynamics Pharmacokinetics Drug Discovery Receptors Drug Ligands Thermodynamics

Pharmaceutical Sciences LibraryRM301.25 T44 2015CHECK SHELVES

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