Title | The Myc Gene [electronic resource] : Methods and Protocols / edited by Laura Soucek, Nicole M. Sodir |
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Imprint | Totowa, NJ : Humana Press : Imprint: Humana Press, 2013 |
Connect to | http://dx.doi.org/10.1007/978-1-62703-429-6 |
Descript | XI, 282 p. 44 illus., 29 illus. in color. online resource |
The Myc world within Reach -- Methods for the Expression, Purification, Preparation and Biophysical Characterization of Constructs of the c-Myc and Max b-HLH-LZs -- Analyzing Myc in Cell Transformation and Evolution -- Identifying Myc Interactors -- Detection of c-Myc Protein-Protein Interactions And Phosphorylation Status by Immunoprecipitation -- An Efficient Way of Studying Protein–Protein Interactions Involving HIF-α, c-Myc, and Sp1 -- Methods for Determining Myc-induced Apoptosis -- Methods to Study Myc-regulated Cellular Senescence -- Chromatin Immunoprecipitation Assays for Myc and N-Myc -- Methods to Quantify microRNAs in the Myc Gene Network for Posttranscriptional Gene Repression -- Genome-wide Analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA-binding by Next Generation Sequencing -- A High Throughput siRNA Screening Platform to Identify MYC Synthetic Lethal Genes as Candidate Therapeutic Targets -- Investigating Myc-dependent Translational Regulation in Normal and Cancer Cells -- Studying Myc’s Role in Metabolism Regulation -- Generation of a Tetracycline Regulated Mouse Model of MYC-induced T-cell Acute Lymphoblastic Leukemia -- Methods to Assess Myc Function in Intestinal Homeostasis, Regeneration and Tumourigenesis -- Detection of c-myc Amplification in Formalin-fixed Paraffin-Embedded Tumor Tissue by Chromogenic in situ Hybridization (CIHS) -- Cell-Based Methods for the Identification of MYC-Inhibitory Small Molecules