Title | Genetic Toxicology [electronic resource] : Principles and Methods / edited by James M. Parry, Elizabeth M. Parry |
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Imprint | New York, NY : Springer New York : Imprint: Springer, 2012 |
Connect to | http://dx.doi.org/10.1007/978-1-61779-421-6 |
Descript | XVI, 433 p. 114 illus., 46 illus. in color. online resource |
The Application of Structure Activity Relationships to the Prediction of the Mutagenic Activity of Chemicals -- Bacterial Mutagenicity Assays: Test Methods -- The Mouse Lymphoma Assay -- Mammalian Cell HPRT Gene Mutation Assay: Test Methods -- The In Vitro Mammalian Chromosome Aberration Test -- The Interpretation and Analysis of Cytogenetic Data -- The In Vitro Micronucleus Assay -- The In Vitro and In Vivo Comet Assays -- Assessment of DNA Interstrand Crosslinks (ICLs) Using the Modified Alkaline Comet Assay -- 32P-Postlabelling for the Sensitive Detection of DNA Adducts -- Methods for the Detection of DNA Adducts -- The GADD45a-GFP GreenScreen HC Assay -- Real Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR): Technical Considerations for Gene Expression Analysis -- Cytogenetic In Vivo Assays in Somatic Cells -- Cytogenetic Methods in Human Biomonitoring: Principles and Uses -- The Measurement of Induced Genetic Change in Mammalian Germ Cells -- Transgenic Animal Mutation Models: A Review of the Models and How They Function -- Analysis of Genotoxicity Data in a Regulatory Context