Title | Drug Design and Discovery [electronic resource] : Methods and Protocols / edited by Seetharama D. Satyanarayanajois |
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Imprint | Totowa, NJ : Humana Press, 2011 |
Connect to | http://dx.doi.org/10.1007/978-1-61779-012-6 |
Descript | XI, 284 p. online resource |
Virtual Screening for Lead Discovery -- Computer-Aided Drug Discovery and Development -- Using Active Site Mapping and Receptor-Based Pharmacophore Tools: Prelude to Docking and De Novo/Fragment-Based Ligand Design -- Methods for Evaluation of Structural and Biological Properties of Anti-Invasive Natural Products -- Solid-Phase Peptide Synthesis Using Microwave Irradiation -- Fluorescent and Lanthanide Labeling for Ligand Screens, Assays, and Imaging -- DNA-Directed Assembly Microarray for Protein and Small Molecule Inhibitor Screening -- Selection of Peptide Ligands for Human Placental Transcytosis Systems Using In vitro Phage Display -- Optimization of the Tetrazolium Dye (MTT) Colorimetric Assay for Cellular Growth and Viability -- Imaging NF- κB Signaling in Mice for Screening Anti-Cancer Drugs -- Evaluation of Anticancer Agents Using Flow Cytometry Analysis of Cancer Stem Cells -- Chemical Screening with Zebrafish Embryos.- iTRAQTM Labeling Coupled with LC-MALDI Mass Spectrometry for Monitoring Temporal Response of Colorectal Cancer Cells to Butyrate Treatment -- Heterotypic Cell Adhesion Assay for the Study of Cell Adhesion Inhibition -- Evaluation of Antibacterial Activity of Proteins and Peptides Using a Specific Animal Model for Wound Healing -- In vitro Immunogenicity Risk Assessment of Therapeutic Proteins in Preclinical Setting