XII, 324p. 188 illus., 94 illus. in color. online resource
SUMMARY
Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain
CONTENT
An Overview of Drug Delivery to the CNS -- Receptor-Mediated Transport of Drugs Across the BBB -- Disruption of Blood–Brain Barrier by Focused Ultrasound for Targeted Drug Delivery to the Brain -- Prediction of Blood–Brain Barrier Penetration by Drugs -- Intraparenchymal Delivery and Its Discontents -- Intrathecal Drug Delivery by Implanted Pumps -- Intracarotid Drug Delivery: Revisiting the Past or Looking into the Future -- Vesicular Systems for Intranasal Drug Delivery -- Convection-Enhanced Drug Delivery and Monitoring in a Rat Model -- Intrathecal Delivery of Stem Cells to the Spinal Cord -- CNS Delivery of Peptides Across the BBB Using the Dual-Artery In Situ Brain Perfusion Model -- An Engineered Peptide Compound Platform Technology Incorporating Angiopep for Crossing the BBB -- Adeno-Associated Virus Mediated Gene Therapy in Ischemic Stroke -- Use of Mesenchymal Stem Cells for Gene Delivery to Intracranial Glioma -- Convection-Enhanced Drug Delivery to the Brain
