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TitleTumor Biomarker Discovery [electronic resource] : Methods and Protocols
Author edited by Michael A. Tainsky
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2009
Connect tohttp://dx.doi.org/10.1007/978-1-60327-811-9
Descript XI, 332 p. 52 illus., 16 illus. in color. online resource

SUMMARY

Through a variety of mechanisms, cancer cells provide the biomarker material that can lead to their own detection, which then grants clinicians the opportunity for non-invasive body fluid and tissue analysis able to indicate the presence of tumors or the level of tumor burden. In Tumor Biomarker Discovery: Methods and Protocols, experts in the field present detailed chapters focused on the use and development of panels of biomarker analytes while covering subjects such as nucleic acids and protein-based technologies, metabolic profiling by analytic means or spectroscopy, as well as study designs for biomarker discovery and validation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials or reagents, step-by-step laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Tumor Biomarker Discovery: Methods and Protocols is an ideal guide to the technologies that can be used to discover and validate tumor biomarker panels suitable for the presymptomatic early detection of cancer


CONTENT

Identification of Tumor-Associated Antigens as Diagnostic and Predictive Biomarkers in Cancer -- Autoantibodies Against Cancer Antigens -- Discovery of Antibody Biomarkers Using Protein Microarrays of Tumor Antigens Cloned in High Throughput -- Analysis of Glycans on Serum Proteins Using Antibody Microarrays -- Glycoproteomic Analysis by Two-Dimensional Electrophoresis -- All-Liquid Separations, Protein Microarrays, and Mass Spectrometry to Interrogate Serum Proteomes: An Application to Serum Glycoproteomics -- Reverse-Phase Protein Microarrays for Theranostics and Patient Tailored Therapy -- Serum Proteomics Using Mass Spectrometry -- Hormones as Biomarkers: Practical Guide to Utilizing Luminex Technologies for Biomarker Research -- High-Throughput Analysis of Serum Antigens Using Sandwich ELISAs on Microarrays -- Tissue Microarrays as a Tool in the Discovery and Validation of Tumor Markers -- Quantitative, Fluorescence-Based In-Situ Assessment of Protein Expression -- Tumor Marker Discovery by Expression Profiling RNA from Formalin Fixed Paraffin Embedded Tissues -- High-Throughput Mutation Screening Using a Single Amplification Condition -- DNA Sequencing of Cancer-Related Genes for Biomarker Discovery -- Analysis of Loss of Heterozygosity in Circulating DNA -- Pharmacogenomics -- Study Designs in Genetic Epidemiology -- Developing Classifiers for the Detection of Cancer Using Multi-Analytes -- Metabolomics of Cancer -- MRI and MRS of Human Brain Tumors -- Magnetic Resonance Spectroscopy of Living Tissues


Medicine Cancer research Laboratory medicine Oncology Medicine & Public Health Oncology Cancer Research Laboratory Medicine



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