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TitleNeuroproteomics [electronic resource] : Methods and Protocols
Author edited by Andrew K. Ottens, Kevin K.W. Wang
ImprintTotowa, NJ : Humana Press : Imprint: Humana Press, 2009
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Descript XI, 321 p. 51 illus. online resource


With the development of polypeptide ionization processes for mass spectrometry and the rapid processing of large-scale datasets with bioinformatics, researchers now have the tools necessary to propel neuroproteomics research to new levels. In Neuroproteomics: Methods and Protocols, experts in the neurological and analytical sciences present experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. Divided into four convenient sections, this collection covers CNS animal models used for neuroproteomics research, methods for separating and analyzing discrete subcomponents of the neuroproteome, large-scale approaches for CNS proteome characterization and quantification, as well as methods that evaluate biofluids and translate neuroproteomic results into clinical platforms. As a volume in the highly successful Methods in Molecular Biology™ series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neuroproteomics: Methods and Protocols includes the clear "how-to" information needed to critically assess what can be accomplished in the field and how to best perform and evaluate neuroproteomic experiments in one’s own research


Disease Models in Neuroproteomics -- The Methodology of Neuroproteomics -- Modeling Cerebral Ischemia in Neuroproteomics -- Clinical and Model Research of Neurotrauma -- Neuroproteomic Methods in Spinal Cord Injury -- Modeling Substance Abuse for Applications in Proteomics -- Protein Aggregate Characterization in Models of Neurodegenerative Disease -- Sub-Proteome Separations and Neuroproteomic Analysis -- Sub-Proteome Processing: Isolation of Neuromelanin Granules from the Human Bra -- Proteomic Analysis of Protein Phosphorylation and Ubiquitination in Alzheimer’s Disease -- Proteomics Identification of Carbonylated and HNE-Bound Brain Proteins in Alzheimer’s Disease -- Mass Spectrometric Identification of In Vivo Nitrotyrosine Sites in the Human Pituitary Tumor Proteome -- Improved Enrichment and Proteomic Analysis of Brain Proteins with Signaling Function by Heparin Chromatography -- Calmodulin-Binding Proteome in the Bra -- Neuroproteomic Methodology and Bioinformatics -- Separation of the Neuroproteome by Ion Exchange Chromatography -- iTRAQ-Based Shotgun Neuroproteomics -- Methods in Drug Abuse Neuroproteomics: Methamphetamine Psychoproteome -- Shotgun Protein Identification and Quantification by Mass Spectrometry in Neuroproteomics -- Biofluid Analysis and Clinical Translation -- Identification of Glycoproteins in Human Cerebrospinal Fluid -- Mass Spectrometric Analysis of Body Fluids for Biomarker Discovery -- Traumatic Brain Injury Biomarkers: From Pipeline to Diagnostic Assay Development -- Translation of Neurological Biomarkers to Clinically Relevant Platforms

Medicine Human physiology Neurosciences Neurology Cell physiology Neurobiology Medicine & Public Health Neurology Neurobiology Neurosciences Human Physiology Cell Physiology


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