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TitleOncogene-Induced Senescence [electronic resource] : Methods and Protocols
Author edited by Mikhail A. Nikiforov
ImprintNew York, NY : Springer New York : Imprint: Humana Press, 2017
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Descript XI, 220 p. 32 illus., 23 illus. in color. online resource


This book offers in a single volume a unique collection of the state-of-the-art experimental procedures utilized for the induction, detection, and modeling of this complex cellular program of oncogene-induced senescence. The book encompasses protocols for studying this multi-step program in human specimens and a variety of experimental models including cultured mammalian cells, laboratory mice, and Drosophila melanogaster, as well as offering a description of high throughput approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Oncogene-Induced Senescence: Methods and Protocols represents a valuable asset for a wide audience of medical oncologists and researchers in the fields of oncology, molecular and cellular biology, biochemistry, and animal development


The Immortal Senescence -- Senescence Phenotypes Induced by Ras in Primary Cells -- Cellular Model of p21-Induced Senescence -- Detecting Markers of Therapy-Induced Senescence in Cancer Cells -- Genome-Wide miRNA Screening for Genes Bypassing Oncogene-Induced Senescence -- Detection of Dysfunctional Telomeres in Oncogene-Induced Senescence -- RT-qPCR Detection of Senescence-Associated Circular RNAs -- Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy -- Detecting the Senescence-Associated Secretory Phenotype (SASP) by High Content Microscopy Analysis -- Sudan Black B, the Specific Histochemical Stain for Lipofuscin: A Novel Method to Detect Senescent Cells -- Using [U-13C6]-Glucose Tracer to Study Metabolic Changes in Oncogene-Induced Senescence Fibroblasts -- Detection of the Ubiquitinome in Cells Undergoing Oncogene-Induced Senescence -- Detection of Reactive Oxygen Species in Cells Undergoing Oncogene-Induced Senescence -- Detection of Senescent Cells by Extracellular Markers Using a Flow Cytometry-Based Approach -- Metabolic Changes Investigated by Proton NMR Spectroscopy in Cells Undergoing Oncogene-Induced Senescence -- Detection of Nucleotide Disbalance in Cells Undergoing Oncogene-Induced Senescence -- Senescence-Like Phenotypes in Human Nevi -- Detection of Oncogene-Induced Senescence In Vivo -- Detection of Senescence Markers During Mammalian Embryonic Development -- Induction and Detection of Oncogene-Induced Cellular Senescence in Drosophila

Medicine Cancer research Biomedicine Cancer Research


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