Title | Computational Design of Ligand Binding Proteins [electronic resource] / edited by Barry L. Stoddard |
---|---|
Imprint | New York, NY : Springer New York : Imprint: Humana Press, 2016 |
Connect to | http://dx.doi.org/10.1007/978-1-4939-3569-7 |
Descript | XVI, 375 p. 94 illus., 76 illus. in color. online resource |
In silico Identification and Characterization of Protein-Ligand Binding Sites -- Computational Modeling of Small Molecule Ligand Binding Interactions and Affinities -- Binding Site Prediction of Proteins with Organic Compounds or Peptides Using GALAXY Web Servers -- Rosetta and the Design of Ligand Binding Sites -- PocketOptimizer and the Design of Ligand Binding Sites -- Proteus and the Design of Ligand Binding Sites -- A Structure Based Design Protocol for Optimizing Combinatorial Protein Libraries -- Combined and Iterative Use of Computational Design and Directed Evolution for Protein-Ligand Binding Design -- Improving Binding Affinity and Selectivity of Computationally Designed Ligand Binding Proteins Using Experiments -- Computational Design of Multinuclear Metalloproteins Using Unnatural Amino Acids -- De Novo Design of Metalloproteins and Metalloenzymes in a Three-helix Bundle -- Design of Light-Controlled Protein Conformations and Functions -- Computational Introduction of Catalytic Activity into Proteins -- Generating High Accuracy Peptide Binding Data in High Throughput with Yeast Surface Display and SORTCERY -- Design of Specific Peptide-Protein Recognition -- Computational Design of DNA-binding Proteins -- Motif-driven Design of Protein-Protein Interfaces -- Computational Reprogramming of T Cell Antigen Receptor Binding Properties -- Computational Modeling of T Cell Receptor Complexes -- Computational Design of Protein Linkers -- Modeling of Protein-RNA Complex Structures Using Computational Docking Methods