การพัฒนาไคทินพิกเคอริงอิมัลชันเพื่อการนำส่งยาผ่านผิวหนังมนุษย์จากการศึกษายานาพรอกเซน / สุกันยา รักศิลป์ = Development of chitin pickering emulsion for human cadaver skin transdermal based on a case of naproxen / Sukanya Raksin
In this study, the capability of naproxen encapsulation in emulsion based chitin microcapsules was investigated. Emulsion based chitin microcapsule was prepared by using chitin particle as solid emulsifier which can be functioned as protective barrier of the inside payload. Skin permeation of naproxen from emulsion based chitin microcapsules was studied through human cadaver skin. The influence of concentration of chitin particles (1, 3 % w/v) to the permeation of naproxen through human cadaver skin was investigated. Isopropyl myristate (IPM) has been used for penetration enhancer. Naproxen was incorporated into an oil phase before emulsification. For both emulsions prepared by using chitin particle concentration of 1 and 3 % w/v emulsion droplet size were approximately 470-900 nm when the amount of incorporated naproxen was about 6 mg/ml. The droplet size of drug incorporated emulsion was similar to that of no drug incorporated one. After transdermal permeation through human skin test, it was found that the emulsion prepared by using 1%w/v chitin particle (P= 0.065 cm h⁻¹) had higher drug permeability than that of using 3%w/v chitin particle (P= 0.050 cm h⁻¹). Therefore, chitin microcapsule prepared via oil-in-water emulsion was suitable for lipophilic drug encapsulation which an approach for medical and pharmaceutical applications.
