Contributions of Physiology to the Understanding of Diabetes [electronic resource] : Ten Essays in Memory of Albert E. Renold / edited by Gaston R. Zahnd, Claes B. Wollheim
Imprint
Berlin, Heidelberg : Springer Berlin Heidelberg, 1997
Recent developments in research on diabetes mellitus embrace basic disciplines such as physiology, biochemistry, morphology, and evolving subspecialities. Fundamental studies on the heterogeneous diabetic syndrome are directed towards regulatory principles of cell metabolism, genetic control mechanisms of insulin biosynthesis, and secretion as well as autoimmune events implicated in selective destruction of the pancreatic ร{159}-cell. At the same time, efforts are being made to better understand normal and impaired bilogical action of insulin and insulin-like growth factor I and the translocation process of glucose transporters in insulin-responsive target cells. The above topics are presented in ten interrelated essays written by renowned experts. The authors offer an integrated view on the development of their work and perspectives in their fields. The present volume is dedicated in reverence to the late Albert Renold, a founding father of the European Association for the Study of Diabetes, for his visionay leadership
CONTENT
Thoughts on the Regulation of Adenylyl Cyclase Systems by Hormone-Sensitive G-Proteins: A Tribute to Albert E. Renold -- Anabolic Response to Cell Swelling in the Liver -- Intercellular Communication and Insulin Secretion -- Expression of the Insulin Gene and Its Regulation -- Implications of the Glucokinase Glucose Sensor Paradigm for Pancreatic ?-Cell Function -- How Ca2+ and Other Signalling Pathways Control the Exocytosis of Insulin in the ?-Cell -- The Mechanism of Insulin Receptor Binding, Activation and Signal Transduction -- Cell Biology of Insulin Action on Glucose Transport: Looking Back -- Insulin-like Growth Factor: Endocrine and Autocrine/Paracrine Implications and Relations to Diabetes Mellitus -- On the Pathogenesis of Insulin-Dependent Diabetes Mellitus in Man: A Paradigm in Transition -- Selected References from the Bibliography of Albert E. Renold, M.D
