Title | Risk and Progression Factors in Carcinogenesis [electronic resource] / edited by H. K. Mรผller-Hermelink, H.-G. Neumann, W. Dekant |
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Imprint | Berlin, Heidelberg : Springer Berlin Heidelberg, 1997 |
Connect to | http://dx.doi.org/10.1007/978-3-642-60393-8 |
Descript | XII, 394p. 129 illus. online resource |
I. Interaction of Carcinogens with Cellular DNA -- Induction of Frameshift Mutations at Hotspot Sequences by Carcinogen Adducts -- Oxidative DNA Damage Induced by Dioxetanes, Photosensitizing Ketones, and Photo-Fenton Reagents -- Oxidative DNA Damage Profiles in Mammalian Cells -- Chemical Mechanisms of Formation of DNA-Carcinogen Adducts, Elucidation of Potential of Adducts for Mutagenicity, and Mechanisms of Polymerase Fidelity and Mutation in the Presence of Adducts -- Assessment of the Tumor-Initiating Potential of ?,?-Unsaturated Carbonyl Compounds by 32P Postlabeling Quantification of DNA Adducts In Vivo -- Glutathione-Dependent Bioactivation and Renal Toxicity of Xenobiotics -- Ultraviolet-Induced Photolesions: Repair and Mutagenesis -- Psoralen Photobiology: The Relationship Between DNA Damage, Chromatin Structure, Transcription, and Immunogenic Effects -- II. Analysis of Cellular Alterations and Growth Dysregulation in Cancer Cells -- Cellular Stress Response: Stress Proteins โ Physiology and Implications for Cancer -- Two-Dimensional Polyacrylamide Gel Electrophoresis of Cancer-Associated Proteins -- Mechanisms Leading to the Expression of Recessive Alleles: The Use of Polymorphic Microsatellites and Whole-Chromosome Painting Probes to Analyze Mouse Tumors, Mtants, and Micronuclei -- Formation of Micronuclei and Inhibition of Topoisomerase II in the Comet Assay in Mammalian Cells with Altered DNA Methylation -- Poly(ADP-Ribosyl)ation and Nuclear Matrix/Intermediate Filament Proteins in Renal Carcinogenesis -- Genotoxic and Chronic Toxic Effects in the Carcinogenicity of Aromatic Amines -- Analysis of Genetic Factors and Molecular Mechanisms in the Development of Hereditary and Carcinogen-Induced Tumors of Xiphophorus -- The Role of Raf Kinases in Development and Growth of Tumors -- Apoptosis Regulation by Raf, Bcl-2, R-Ras -- New Cell Cycle-Regulated Genes in the Yeast Saccharomyces cerevisiae -- The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth -- III. Selected Findings in Human Tumors -- Growth and Transformation of Human Oral Epithelium In Vitro -- Genetic Lesions in Mantle Cell Lymphoma -- Topoisomerase Activities in Undifferentiated Acute Myeloblastic Leukemias and Monocytic Differentiated Leukemias -- DNA Repair: Genes, Enzymes, Patients, and Mouse Models -- Repair of Directly and Indirectly UV-Induced DNA Lesions and of DNA Double-Strand Breaks in Cells from Skin Cancer-Prone Patients with the Disorders Dysplastic Nevus Syndrome or Basal Cell Nevus Syndrome -- Exploring the Role of Oxygen in Fanconis Anemia -- P53 Gene Alterations in Human Tumors: Perspectives for Cancer Control