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TitleBiological Matrices and Tissue Reconstruction [electronic resource] / edited by G. Bjรถrn Stark, Raymund Horch, Eszter Tร{129}czos
ImprintBerlin, Heidelberg : Springer Berlin Heidelberg, 1998
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Descript XXIX, 288p. 110 illus., 19 illus. in color. online resource


C.A. VACANTI The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in human health care. Advances in the medical sciences have enabled physicians to restore lost functions in their patients through orยญ gan transplantation, reconstructive surgery with autogenous tissue transfer, or the implantation of alloplastic materials. Although only recently termed "Tissue Engineering" [1], the use of biological andlor synthetic materials in conjunction with cells to create biologic substitutes to serve as functional tisยญ sue replacements has been explored by modern scientists for several decades. The concept of generating functional tissue from an organ biopsy was deยญ scribed very early in the literature: "The Lord God cast a deep sleep on the man, and while he was asleep, he took out one of his ribs and closed up its place with flesh. The Lord God then built up into a woman the rib that he had taken from the man" [2]. Review of history further reveals that, according to legend, the first homotransplantation of an entire limb was performed by Saints Damian and Cosmas, as depicted by the artist Fra Angelico


I Wound Healing -- 1 Wound Healing in Surgery -- 2 Influence of Collagen Membranes and Collagenous Sponge Material in the Connective Tissue Matrix. An Immunohistochemical Study -- 3 Collagen Matrix Implantation for Tissue Repair and Wound Healing. Present and Perspectives -- 4 Characterization of Biomaterial for Tissue Repair -- Discussion to Part I โ{128}{148} Wound Healing Properties of Different Tissue Sealants -- II Gene Therapy and Growth Factors -- 5 Genetically Modified Fibroblasts-Fibrin-Glue Suspension for In Vivo Drug Delivery of Epidermal Growth Factor (EGF): A Surface Gene Therapy Model not only for Wounds -- 6 Genetically Modified Fibroblasts induce Angiogenesis in the Rat Epigastric Island Flap -- 7 Stimulation of Growth and Proliferation of Human Keratinocytes by KGF-Transfected Cells In Vitro -- 8 Genetically Modified Human Keratinocyte Clone Secrets EGF -- III Keratinocytes and Skin Reconstruction -- 9 Fibrin-Glue as a Carrier for Cultured Human Keratinocytes versus Cultured Epidermal Skin Grafts in Athymic Mice Full-Thickness Wounds -- 10 Enhanced Expression of Integrin Receptors during Proliferation of Activated Keratinoblasts Prepared for Transplantation as Cell Suspension in Fibrinous Matr -- 11 Autologous ORS-Keratinocytes in the Therapy of Chronic Leg Ulcers -- IV Visceral and Internal Tissues -- 12 Transplantation of Autologous Cultured Urothelium Cells onto a Prefabricated Capsule in Rats -- 13 Urothelial Cell Culture Behaviour in Fibrin Glue Compared to Conventional Culture Medium -- 14 Autologous Transplantation of Urothelium into Demucosalized Gastrointestinal Segments -- 15 Co-Cultured Human Liver Epithelial Cells in Collagen Gel: A Source for Tissue Engineering in Vitro -- 16 Clinical Use of Autologous Endothelial Cell Seeded PTFE Vascular Grafts for Coronary Artery Revascularization -- 17 Influence of Fibrinogen Adhesives and their Components on Growth and Attachment of Human Endothelial Cells -- V Cartilage -- 18 The Effect of Long Term Culture on the Ability of Human Auricular Cartilage Chondrocytes to Generate Tissue Engineered Cartilage -- 19 Tissue Engineered Cartilage with Cultured Chondrocytes and a Collagen Sponge Matrix -- 20 Chondrocyte-Differentiation in Fibrin-Coating Polytetrafluorethylen-Membrane -- 21 In Vitro Engineered Cartilage for Reconstructive Surgery, Using Biocompatible, Resorable Fibrin Glue/Polymer Structures -- 22 Autologous Chondrocyte Transplantation โ{128}{148} Chondrocyte Culturing and Clinical Aspects -- VI Bone -- 23 Matrix and Carrier Materials for Bone Growth Factors: State of the Art and Future Perspectives -- 24 Delivery System for Osteoinductive Proteins -- VIl Muscle, Nerves and Tendons -- 25 Tissue Engineering of Skeletal Muscle Using Micropatterned Biomaterials -- 26 Tissue Engineered Nerve Conduits: The Use of Biodegradable Poly-DL-Lactic-Co-Glycolic Acid (PLGA) Scaffolds in Peripheral Nerve Regeneration -- 27 Tissue Engineered Collagen Nerve Guidance Channels -- 28 The Role of Fibrin Glue as Provisional Matrix in Tendon Healing -- VIII Varia -- 29 Wound Healing, Fluid and Protein Balance in Severe Burns following Topical Application of Clotting Factors -- 30 Primary Human Osteoblast Cultures on Different Biomaterials -- 31 Transfection of Human Keratinocytes in Vitro with the Particle Mediated Gene Transfer and the Liposomeโ{128}{148}Mediated Gene Transfer Method -- 32 Therapeutic Angiogenesis in Wounds: The Influence of Growth Factors at a Muscle Flap-Ischemic Tissue Interface

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