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AuthorReginster, J.-Y. author
TitleOsteoarthritis [electronic resource] : Clinical and Experimental Aspects / by J.-Y. Reginster, J.-P. Pelletier, J. Martel-Pelletier, Y. Henrotin, L. Crasborn
ImprintBerlin, Heidelberg : Springer Berlin Heidelberg, 1999
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Descript XIV, 509 p. 68 illus., 26 illus. in color. online resource


This book is written by worldwide renowned researchers and clinicians in the field of OSTEOARTHRITIS. Latest experimental results in osteoarthritis research are reported. The book describes in detail all aspects of this disease - from pathophysiology and diagnostics to medical, surgical and physical therapy and rehabilitation. This work represents a summary of the current status of clinical and experimental aspects of osteoarthritis


1 Structure and Function of Normal Human Adult Articular Cartilage -- 2 Epidemiology and Economic Consequences of Osteoarthritis -- 2.1 The American Viewpoint -- 2.2 The European Viewpoint -- 3 Experimental Models of Osteoarthritis -- 3.1 In Vitro Models for the Study of Cartilage Damage and Repair -- 3.2 Animal Models of Osteoarthritis -- 4 Pathophysiology of Osteoarthritis -- 4.1 Role of Mechanical Factors in the Aetiology, Pathogenesis and Progression of Osteoarthritis -- 4.2 Role of Biomechanical Factors -- 4.3 Genetic and Metabolic Aspects -- 4.4 Biochemical Factors in Joint Articular Tissue Degradation in Osteoarthritis -- 4.5 Role of Growth Factors and Cartilage Repair -- 4.6 Role of Crystal Deposition in the Osteoarthritic Joint -- 5 Diagnosis and Monitoring of Osteoarthritis -- 5.1 Direct Visualization of the Cartilage -- 5.2 Radiographic Imaging of Osteoarthritis -- 5.3 Magnetic Resonance Imaging in Osteoarthritis -- 5.4 The Role of Molecular Markers to Monitor Breakdown and Repair -- 6 Evolution and Prognosis of Osteoarthritis -- 7 Impact of Osteoarthritis on Quality of Life -- 8 Medical Management of Osteoarthritis -- 8.1 Medical Aspects -- 8.1.1 Basic Principles in Osteoarthritis Treatment -- 8.1.2 Non-steroidal Anti-inflammatory Drug Administration in the Treatment of Osteoarthritis -- 8.1.3 New and Future Therapies for Osteoarthritis -- 8.2 Regulatory Requirements -- 8.2.1 Preclinical Studies in Osteoarthritis -- 8.2.2 Clinical Evaluation of Drug Therapy -- 9 Surgical Treatment of the Cartilage Injuries -- 10 Scientific Basis of Physical Therapy and Rehabilitation in the Management of Patients with Osteoarthritis -- 11 Conclusion and Perspectives

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