Author | Reginster, J.-Y. author |
---|---|
Title | Osteoarthritis [electronic resource] : Clinical and Experimental Aspects / by J.-Y. Reginster, J.-P. Pelletier, J. Martel-Pelletier, Y. Henrotin, L. Crasborn |
Imprint | Berlin, Heidelberg : Springer Berlin Heidelberg, 1999 |
Connect to | http://dx.doi.org/10.1007/978-3-642-60026-5 |
Descript | XIV, 509 p. 68 illus., 26 illus. in color. online resource |
1 Structure and Function of Normal Human Adult Articular Cartilage -- 2 Epidemiology and Economic Consequences of Osteoarthritis -- 2.1 The American Viewpoint -- 2.2 The European Viewpoint -- 3 Experimental Models of Osteoarthritis -- 3.1 In Vitro Models for the Study of Cartilage Damage and Repair -- 3.2 Animal Models of Osteoarthritis -- 4 Pathophysiology of Osteoarthritis -- 4.1 Role of Mechanical Factors in the Aetiology, Pathogenesis and Progression of Osteoarthritis -- 4.2 Role of Biomechanical Factors -- 4.3 Genetic and Metabolic Aspects -- 4.4 Biochemical Factors in Joint Articular Tissue Degradation in Osteoarthritis -- 4.5 Role of Growth Factors and Cartilage Repair -- 4.6 Role of Crystal Deposition in the Osteoarthritic Joint -- 5 Diagnosis and Monitoring of Osteoarthritis -- 5.1 Direct Visualization of the Cartilage -- 5.2 Radiographic Imaging of Osteoarthritis -- 5.3 Magnetic Resonance Imaging in Osteoarthritis -- 5.4 The Role of Molecular Markers to Monitor Breakdown and Repair -- 6 Evolution and Prognosis of Osteoarthritis -- 7 Impact of Osteoarthritis on Quality of Life -- 8 Medical Management of Osteoarthritis -- 8.1 Medical Aspects -- 8.1.1 Basic Principles in Osteoarthritis Treatment -- 8.1.2 Non-steroidal Anti-inflammatory Drug Administration in the Treatment of Osteoarthritis -- 8.1.3 New and Future Therapies for Osteoarthritis -- 8.2 Regulatory Requirements -- 8.2.1 Preclinical Studies in Osteoarthritis -- 8.2.2 Clinical Evaluation of Drug Therapy -- 9 Surgical Treatment of the Cartilage Injuries -- 10 Scientific Basis of Physical Therapy and Rehabilitation in the Management of Patients with Osteoarthritis -- 11 Conclusion and Perspectives