Title	Immune Response in the Critically Ill [electronic resource] / edited by John C. Marshall, Jonathan Cohen
Imprint	Berlin, Heidelberg : Springer Berlin Heidelberg, 2002
Connect to	http://dx.doi.org/10.1007/978-3-642-57210-4
Descript	XIV, 427 p. online resource

This book brings together basic scientists or clinicians from a variety of different backgrounds - immunology, infectious diseases or critical care - who share a common interest in understanding the changes that occur in immune responses in sepsis. It provides an up-to-date and unrivalled synthesis of current research in this rapidly developing field

The Four Ds of the Danger Model: Distress, Damage, Destruction, and Death -- The Immune Response in Critical Illness: Excessive, Inadequate or Dysregulated -- Genomics of the Sepsis Syndrome -- The Pro-Inflammatory Cytokine Cascade -- Inhibitory Cytokines -- Interleukin-1? and Interleukin-18: Two Cytokine Precursors for Interleukin-1? Converting Enzyme (Caspase-1) -- Bacterial Toxins Induce Specific Cytokine Patterns In Vivo and In Vitro -- The Acute Phase Response and Enhancing Resistance to Bacterial Infection -- Cytokines as Mediators of Lung Innate Immunity -- Fetuin Opsonizes Macrophage-Deactivating Cations -- LPS Receptors -- Regulation of Cellular Responses to Bacterial Endotoxin -- The Role of Nitric Oxide in the Initiation of Inflammation in Shock -- Regulation of Neutrophil Activation in Acute Lung Injury and SIRS -- Neutrophils and Acute Lung Injury -- Lymphocyte Activation, Anergy, and Apoptosis in Polymicrobial Sepsis -- Trauma Mediators Favor Differentiation of Monocytes to Macrophage Rather Than to Dendritic Cells -- Programmed Cell Death (Apoptosis) and the Immunologic Derangements of Critical Illness -- The Interaction Between the Coagulation System and the Systemic Inflammatory Mediators -- The Endothelium as an Immune Organ: Active Player and Passive Target -- Immunoregulation in Shock, Trauma, and Sepsis -- Endotoxemia in Healthy Subjects as a Human Model of Inflammation -- Monitoring Immune Status in Critically Ill Patients -- Tumor Necrosis Factor Receptors in Systemic Inflammation -- Cytokine Neutralization: An Overview -- Immunostimulation with Cytokines in Patients with โ{128}{152}Immunoparalysisโ{128}{153} -- Prospects for a Vaccine to Prevent Bacterial Sepsis