Title | Mechanisms of Organ Dysfunction in Critical Illness [electronic resource] / edited by Timothy W. Evans, Mitchell P. Fink |
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Imprint | Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2002 |
Connect to | http://dx.doi.org/10.1007/978-3-642-56107-8 |
Descript | XVI, 410 p. online resource |
Mitochondrial Biology -- Cellular Responses to Hypoxia: Role of Oxidant Signal Transduction -- The Mitochondrial Permeability Transition: A โPore โWay to Die -- Cytopathic Hypoxia in Circulatory Shock: The Role of Poly (ADP-Ribose) Synthetase Activation -- Derangements in Cellular Oxygen Metabolism -- Pharmacologic and Metabolic Mitochondrial Rescue -- Leukocytes and Cell Signaling Mechanisms in Inflammation -- Role of Leukocytes in Sepsis and Lung Injury -- Dysregulated Neutrophil Apoptosis in the Pathogenesis of Organ Injury in Critical Illness -- Does Apoptosis Play a Role in the Development of Sepsis-Induced Myocardial Dysfunction? -- The Intracellular Signaling Pathways of Inflammatory Stress -- Pro-Inflammatory Cytokines: Double-Edged Swords in the Pathogenesis of Bacterial Infection -- Organ-Organ Interactions in Multiple Organ Failure -- Microcirculatory Dysfunction -- Endothelial Cell Dysfunction and Abnormal Tissue Perfusion -- The Microcirculation in Sepsis -- Lung and Kidney -- Pulmonary Vascular Dysfunction -- Pulmonary Epithelial Injury: Clinical and Experimental Evidence for a Major Role in Acute Lung Injury and Multiple Organ Dysfunction -- Ischemia-Induced Derangements in the Actin Cytoskeleton: Mechanisms and Functional Significance -- Multiple Organ Failure and the Kidney -- Apoptosis in Renal Ischemia-Reperfusion Injury -- Gastrointestinal Tract -- Local Muscularis Inflammatory Mechanisms of Ileus -- Mechanisms Responsible for Intestinal Barrier Dysfunction in Critical Illness -- Liver Dysfunction: Nitric Oxide, Carbon Monoxide, and Reactive Oxygen Species -- Brain Injury -- Polyamine Oxidase and 3-Aminopropanal in the Pathogenesis of Cerebral Ischemia -- Key Mechanisms of Secondary Neuronal Damage After Brain Trauma -- Cerebral Ischemia: Pathophysiology and Neuroprotection -- Organ Dysfunction: Detection and Intervention -- Redistribution of Microvascular Oxygen Pressures in the Pig Intestine in Hemodilution and Sepsis -- Influence of Mechanical Ventilation on Organ Dysfunction -- Coagulation Abnormalities in Critical Illness -- Multiple Organ Failure: Clinical Syndrome