Title	Vitamin D Analogs in Cancer Prevention and Therapy [electronic resource] / edited by Jรถrg Reichrath, Wolfgang Tilgen, Michael Friedrich
Imprint	Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2003
Connect to	http://dx.doi.org/10.1007/978-3-642-55580-0
Descript	VIII, 432 p. online resource

This volume provides a comprehensive, highly readable overview of the topics discussed at the First International Symposium on "Vitamin D Analogs in Cancer Prevention and Therapy" held in Homburg/Saar, Germany in May 2002. Leading researchers discuss our present knowledge of the vitamin D system in cancer. Topics range from the newest findings in molecular biology, epidemiology, synthesis and metabolism of vitamin D to new concepts for the use of vitamin D analogs in cancer prophylaxis and treatment. The book provides essential up-to-date information for every researcher or clinician interested in the biology of vitamin D or cancer

1 Molecular Biology of Vitamin D -- Evolution and Function of Vitamin D -- Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural and Synthetic Ligands -- Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk -- Ligand Structureโ{128}{147}Function Relationships in the Vitamin D Endocrine System from the Perspective of Drug Development (Including Cancer Treatment) -- Antiproliferative Signalling by 1,25(OH)2D3 in Prostate and Breast Cancer Is Suppressed by a Mechanism Involving Histone Deacetylation -- Mechanisms Implicated in the Growth Regulatory Effects of Vitamin D Compounds in Breast Cancer Cells -- Squamous Cell Carcinomas Fail to Respond to the Prodifferentiating Actions of 1,25(OH)2D: Why? -- A Novel Vitamin D-Regulated Immediate-Early Gene, IEX-1, Alters Cellular Growth and Apoptosis -- Extrarenal Sites of Calcitriol Synthesis: The Particular Role of the Skin -- Cultured Rat Growth Plate Chondrocytes Express Low Levels of 1a-Hydroxylase -- Gene Amplification and Splice Variants of 25-Hydroxyvitamin D3 1, ?-Hydroxylase (CYP27B1) in Glioblastoma Multiformeโ{128}{148}A Possible Role in Tumor Progression? -- Regulation of the 25-Hydroxyvitamin D-1?-Hydroxylase Gene and Its Splice Variant -- Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolism -- Importance Of Cytochrome P450-Mediated Metabolism in the Mechanism of Action of Vitamin D Analogs -- 2 The Vitamin D System in Cancer -- The Role of Vitamin D in Prostate Cancer -- Vitamin D Autocrine System and Prostate Cancer -- Analysis of the Vitamin D System in Cervical Carcinomas, Breast Cancer and Ovarian Cancer -- Short-Chain Fatty Acids and Colon Cancer Cells: The Vitamin D Receptor-Butyrate Connection -- Analysis of the Vitamin D system in Cutaneous Malignancies -- 3 Antitumor Effects of Vitamin D Analogs -- Evaluation of Vitamin D Analogs as Therapeutic Agents for Prostate Cancer -- Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D3 Analogs -- Induction of Apoptosis by Vitamin D Metabolites and Analogs in a Glioma Cell Line -- Vitamin D Analogs and Breast Cancer -- A Low-Calcemic Vitamin D Analog (Ro 25-4020) Inhibits the Growth of LNCaP Human Prostate Cancer Cells with Increased Potency by Producing an Active 24-Oxo Metabolite (Ro 29โ{128}{147}9970) -- Prospects for Vitamin D receptor Modulators as Candidate Drugs for Cancer and (Auto)immune Diseases -- The Role of Reactive Oxygen Species in the Anticancer Activity of Vitamin D -- 4 Vitamin D in Cancer Prevention -- Ecologic Studies of Solar UV-B Radiation and Cancer Mortality Rates -- Phytoestrogens and 17b-Estradiol Influence Vitamin D Metabolism and Receptor Expression-Relevance for Colon Cancer Prevention -- Efficacy and Mechanism of Action of 1a-hydroxy-24-ethyl-Cholecalciferol (1a[OH]D5) in Breast Cancer Prevention and Therapy -- Regulation of Extrarenal Vitamin D Metabolism as a Tool for Colon and Prostate Cancer Prevention -- Modulation of X-ray-Induced Apoptosis in Human Keratinocytes (HaCaT) by 1, 25-Dihydroxyvitamin D3