Title | New Paradigms of Coronary Artery Disease [electronic resource] : Hibernation, Stunning, Ischemic Preconditioning / edited by Gerd Heusch, Rainer Schulz |
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Imprint | Heidelberg : Steinkopff : Imprint: Steinkopff, 1996 |
Connect to | http://dx.doi.org/10.1007/978-3-642-53793-6 |
Descript | VIII, 182 p. 96 illus. online resource |
Myocardial Hibernation -- I. Short-term hibernation: evidence for downregulation of contractile function and metabolic adaptation -- Critical role of energy supply and glycolysis during short-term hibernation -- Hibernating myocardium represents a primary downregulation of regional myocardial oxygen consumption distal to a critical coronary stenosis -- Myocardial hibernation: relationship to a model for segmental dyskinesis -- Myocardial hibernation in terms of the flow- function relationship -- Contractile pattern in acutely hibernating myocardium -- Excitation-contraction coupling in hibernating myocardium -- Hibernating myocardium: a hypometabolic state for energy conservation -- Myocardial hibernation -- Acute adaptation to ischemia: Short-term hibernating myocardium -- II. Long-term hibernation -- Myocardial hibernation: unresolved physiological and clinical issues -- Hibernating myocardium -- Hibernating myocardium: a brief article -- Myocardial hibernation, stunning, or both? -- Structural aspects of the chronic hibernating myocardium in man -- Hibernating myocardium: adaptation or degeneration? -- The hibernating myocardium: identification of viable myocardium in patients with coronary artery disease and chronic left ventricular dysfunction -- Commentary on hibernating myocardium and its clinical relevance -- Hibernating myocardium, a clinical entity -- Identification of โhibernating myocardiumโ by imaging approaches -- Myocardial Stunning -- I. Definition and occurence -- Ubiquity of myocardial stunning -- II. Methodological and conceptual problems -- Common methodological problems and artifacts associated with studies of myocardial stunning in vivo -- Stunning: Three questions and concerns -- III. Excitation-contraction coupling -- Do ATP-sensitive potassium channels play a role in myocardial stunning? -- Stunned myocardium: a disease of the myofilaments? -- Stunned myocardium, an opinionated review -- IV. Metabolism -- Myocardial stunning: the role of oxidative substrate metabolism -- Adjustments in competitive substrate utilization in stunned myocardium during early reperfusion -- V. Coronary blood flow alterations -- Is stunned myocardium ischemic on a microvascular level? -- Absolute myocardial blood flow in chronic left ventricular dysfunction -- Coronary vasomotion of the stunned myocardium -- VI. Pharmacotherapy -- Therapy for myocardial stunning -- Stunned myocardium: inotropic reserve and pharmacological attenuation -- VII. Clinical relevance: hibernation vs. stunning -- The elusive difference between hibernation and stunning in patients -- Commentary on myocardial stunning and its clinical relevance -- Chronic stunning: The new switch in thought -- Ischemic Preconditioning -- I. Ischemic preconditioning: the concept -- Ischemic preconditioning: a brief review -- Preconditioning โ a reappraisal of protection -- Ischemic preconditioning, remembrances of things past and future -- Three questions about preconditioning -- II. Triggers and mediators of ischemic preconditioning: adenosine, bradykinin, nitric oxide and KATP-channels -- Preconditioning-induced protection against post-ischemic contractile dysfunction: Inhibitory effect of tissue washout -- Adenosine and bradykinin: Are they independent triggers of precondiยฌtioning? -- Activation of Ecto-5?-nucleotidase and cardioprotection by ischemic preconditioning -- Endothelial cells, nitric oxide and ischaemic preconditioning -- Criteria for a mediator or effector of myocardial preconditioning: Do KATP channels meet the requirements? -- III. The controversial role of protein kinase C in ischemic preconditioning -- Preconditioning: Markers vs. epiphenomena -- Limitation of infarct size by myocardial ischemic preconditioning -- Role of protein kinase C in ischemic preconditioning: in search of the โpure and simple truthโ -- IV. Trigger mechanisms other than ischemia: stress and stretch -- Cardioprotection by organs in stress or distress -- An alternative perspective on ischemic preconditioning derived from mathematical modeling -- V. Ischemic preconditioning vs. myocardial hibernation -- Ischemic preconditioning and myocardial hibernation: Is there a common mechanism? -- VI. Second window of protection -- Delayed myocardial protection following ischaemic preconditioning -- The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview