I. Introduction -- 1. Historical Perspective: The Early Years (1930โ{128}{147}1960) -- 2. The Patient's Perspective -- II. Clinical Spectrum -- A. Glandular Findings -- 1. Oral Manifestations of Sjรถgren's Syndrome -- 2. The Eye in Sjรถgren's Syndrome -- 3. Chemistry of Saliva -- 4. Histopathology of Sjรถgren's Syndrome -- B. Extraglandular Findings -- 1. Primary Sjรถgren's Syndrome in the People's Republic of China -- 2. Neuromuscular Complications of Primary Sjรถgren's Syndrome -- 3. The Respiratory System in Sjรถgren's Syndrome -- 4. Gastrointestinal and Hepatobiliary Features in Sjรถgren's Syndrome -- 5. Renal Disease with Sjรถgren's Syndrome -- 6. Inflammatory Vascular Disease in Sjรถgren's Syndrome -- C. Lymphoid Malignancy -- 1. Lymphoid Malignancy and Monoclonal Proteins -- 2. Detection of Lymphoma in Sjรถgren's Syndrome by Analysis of Immunoglobulin Gene Rearrangements -- 3. Lymphoproliferative Disorders in Japanese Patients with Sjรถgren's Syndrome -- D. Relationship to Other Autoimmune Diseases -- 1. Relationship of Sjรถgren's Syndrome to Rheumatoid Arthritis -- 2. Sjรถgren's Syndrome with Systemic Lupus Erythematosus/Mixed Connective Tissue Disease -- 3. Sjรถgren's Syndrome and Systemic Sclerosis (Scleroderma) -- E. Diagnosis and Differential Diagnosis -- 1. Diagnosis and Differential Diagnosis of Sjรถgren's Syndrome -- III. Laboratory Abnormalities -- 1. Rheumatoid Factor in Sjรถgren's Syndrome -- 2. Autoantibodies in Sjรถgren's Syndrome -- 3. Immunogenetics of Sjรถgren's Syndrome -- 4. The Relationship Between Anti-RO(SS-A) Precipitin Antibody Positive Sjรถgren's Syndrome and Anti-RO(SS-A) Precipitin Antibody Positive Lupus Erythematosus -- 5. Immunologic Abnormalities in Sjรถgren's Syndrome -- 6. Animal Models of Sjรถgren's Syndrome -- IV. Treatment of Sjรถgren's Syndrome