Title | Liposome Dermatics [electronic resource] : Griesbach Conference / edited by Otto Braun-Falco, Hans Christian Korting, Howard I. Maibach |
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Imprint | Berlin, Heidelberg : Springer Berlin Heidelberg, 1992 |
Connect to | http://dx.doi.org/10.1007/978-3-642-48391-2 |
Descript | XX, 364 p. online resource |
General Considerations -- Percutaneous Absorption and Conventional Penetration Enhancers -- Lipid Flow Phenomena Between Liposomes, Lipoproteins and Cell Membranes; Applications in Drug Delivery -- Basic Principles of Liposomes for Drug Use -- Chemical Aspects -- Phospholipids as Basic Ingredients -- Liposome Dermatics: Chemical Aspects of the Skin Lipid Approach -- Ceramides for Liposomes -- Liposome Phospholipids: Toxicological and Environmental Advantages -- Physico-chemical Aspects -- Liposome Production: Historic Aspects -- Rationale for the Production and Dermal Application of Lipid Vesicles -- Liposome Production: The Ethanol Injection Technique and the Development of the First Approved Liposome Dermatic -- Liposome Production: The Sizing-Up Technology Starting from Mixed Micelles and the Scaling-Up Procedure for the Topical Glucocorticoid Betamethasone Dipropionate and Betamethasone -- Properties and Characterization of Pre-Liposome Systems -- Technological Aspects -- Changes in the Structure of the Human Stratum Corneum Induced by Liposomes -- Monitoring in vivo Skin Hydration by Liposomes Using Infrared Spectroscopy in Conjunction with Tape Stripping -- Liposome Dermatics: Assessment of Long-Term Stability -- Delivery of Liposome-Encapsulated Agents to Artificial Membranes -- Topical Delivery of Liposomally Encapsulated Ingredients Evaluated by In Vitro Diffusion Studies -- Pre-Clinical Aspects: Kinetics and Toxicology -- The Fate of Liposomes in Animal Skin -- The Fate of Liposomes for Topical Use in Skin Tissue Culture -- Liposomally Encapsulated Active Ingredients Penetrate Through the Follicle -- Biodisposition of Liposome-Encapsulated Active Ingredients Applied on the Skin -- Distribution of Liposome-Encapsulated Ingredients in Human Skin Ex Vivo -- Liposomes as Safe Carriers of Drugs and Vaccines -- Pre-Clinical Aspects: Dynamics -- Comedolytic Activity of a Liposomal Antiacne Drug in an Experimental Model -- Topical Delivery of Liposomally Encapsulated Interferon Evaluated by in Vitro Diffusion Studies and in a Cutaneous Herpes Guinea Pig Model -- Comparative Activity of a Liposomal and a Conventional Econazole Preparation for Topical Use According to a Guinea Pig Tinea Model -- Liposome-Encapsulated Enzymes for DNA Repair -- Patent and Regulatory Aspects -- General Remarks on Patent Matter -- Liposome Determatics to Come According to the Patent Literature -- Clinical Regulatory Aspects of Topical Liposomal Drugs with Special Consideration of Safety Aspects -- Clinical Aspects -- Clinical Trial Protocols for Anti-Inflammatory and other Liposome Dermatics -- Chemical Composition of Liposomes and Its Influence on the Humidity of Normal Skin -- Influence of Various Topical Liposome Preparations With and Without Active Ingredients on the Cutaneous Blood Flow -- Increased Activity and Tolerability of a Conventional Glucocorticoid in a Liposomal Form -- Influence of Liposomal Encapsulation on the Activity of a Herbal Non-Steroidal Anti-Inflammatory Drug -- Future Prospects -- Past, Present and Future of Liposome Cosmetics -- Liposomes in Drug Delivery: Present and Future