Title | Genes and Environment in Cancer [electronic resource] / edited by Manfred Schwab, Hartmut M. Rabes, Klaus Munk, Hans Peter Hofschneider |
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Imprint | Berlin, Heidelberg : Springer Berlin Heidelberg, 1998 |
Connect to | http://dx.doi.org/10.1007/978-3-642-46870-4 |
Descript | XIV, 368p. 58 illus., 8 illus. in color. online resource |
I. Key Notes -- Epidemiological Evidence of the Effects of Behaviour and the Environment on the Risk of Human Cancer -- Molecular Epidemiology of Human Cancer -- II. Risk Assessment and DNA Lesions -- Molecular Epidemiology of Environmental Carcinogenesis -- Polymorphisms of N-Acetyltransferases, Glutathione S-Transferases, Microsomal Epoxide Hydrolase and Sulfotransferases: Influence on Cancer Susceptibility -- Impact of Adduct Determination on the Assessment of Cancer Susceptibility -- Mutation Spectra Resulting from Carcinogenic Exposure: From Model Systems to Cancer-Related Genes -- III. DNA Repair and Genetic Susceptibility -- Relevance of DNA Repair to Carcinogenesis and Cancer Therapy -- Molecular Basis of DNA Repair Mechanisms and Syndromes -- The Ataxia Telangiectasia Gene in Familial and Sporadic Cancer -- IV. Induced Chromosome Damage and Cancer -- Cancer Predictive Value of Cytogenetic Markers Used in Occupational Health Surveillance Programs -- Instability at Chromosomal Fragile Sites -- The Role of Deletions at the FRA3B/FHIT Locus in Carcinogenesis -- Gene Amplification Mechanisms: The Role of Fragile Sites -- V. Genetic Susceptibility and Environmental Exposure: โThe RET Paradigmโ -- Mechanisms of Development of Multiple Endocrine Neoplasia Type 2 and Hirschsprungโs Disease by ret Mutations -- Rearrangements of RET and NTRK1 Tyrosine Kinase Receptors in Papillary Thyroid Carcinomas -- Molecular Genetics of Childhood Papillary Thyroid Carcinomas After Irradiation: High Prevalence of RET Rearrangement -- Thyroid Carcinomas in RET/PTC Transgenic Mice -- Signal Transduction by the Receptor Tyrosine Kinase Ret -- VI. Population Genetics of Cancer Susceptibility -- Complex Traits on the Map -- Genetic Mapping of Cancer Susceptibility/Resistance Loci in the Mouse -- Cancer Epidemiology in Migrant Populations -- Molecular Epidemiology of Hereditary Nonpolyposis Colorectal Cancer in Finland -- VII. Virus and Cancer: The HBV/HCV Paradigm -- The PreS2 Activators of the Hepatitis B Virus: Activators of Tumour Promotor Pathways -- Antiviral Cell-Mediated Immune Responses During Hepatitis B and Hepatitis C Virus Infections -- The Role of Hepatitis C Virus in Hepatocellular Carcinoma -- Overview of Viruses, Cancer, and Vaccines in Concept and in Reality