Title | Perspectives in Antiinfective Therapy [electronic resource] / edited by George Gee Jackson, H. D. Schlumberger, H.-J. Zeiler |
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Imprint | Berlin, Heidelberg : Springer Berlin Heidelberg, 1989 |
Connect to | http://dx.doi.org/10.1007/978-3-642-46666-3 |
Descript | XVII, 478p. 101 illus. online resource |
The Challenge of Perspective -- History and Philosophy of Bayer Pharmaceutical Research -- On Bacteriological Research -- Background to Robert Kochโs Lecture at the International Congress in Berlin, 1890 -- Classical Mechanisms of Antibacterial Drags -- Multiple Penicillin Binding Protein Profiles in Penicillin Resistant Pneumococi: Evidence for the Clonal Nature of Resistance Among Clinical Isolates -- Antibiotic Uptake into Gram-Negative Bacteria -- Inhibition of Protein Biosynthesis by Antibiotics -- Inhibition of DNA Gyrase: Bacterial Sensitivity and Clinical Resistance to 4-Quinolones -- Mechanisms of Nonbacterial Antiinfective Drags -- Mechanisms of Antiretroviral Compounds in Inhibition of Viral and Cellular DNA Polymerases -- Effects of Drugs on Lipids and Membrane Integrity of Fungi -- Membrane Changes Induced by Praziquantel -- Mechanisms of Action of Antimalarial Drugs -- Pathogenic Microbial Mechanisms Susceptible to Drug Application -- Bacterial Adherence in Pathogenicity -- Haemophilus influencae Gene Expression and Bacterial Invasion -- Coordinate Regulation of Bacterial Virulence Genes -- Microbial Drug Resistance -- Transposon Transfer of Drug Resistance -- Bacterial Proteins Involved in Antimicrobial Drug Resistance -- Persistent Herpes Simplex Virus Infection and Mechanisms of Virus Drug Resistance -- Pharmacology and Drug Delivery -- Antiviral Therapy with Small Particle Aerosols -- Liposomes and Lipid Structures as Carriers of Amphotericin B -- Targeted Liposomes Bearing Sendai for Influenza Envelope Glycoproteins as a Potential Carrier for Protein Molecules and Genes -- Host Determinants in Antiinfective Chemotherapy -- Cell-Mediated Immunity, Immunodeficiency and Microbial Infections -- Neutropenia: Antibiotic Combinations for Empiric Therapy -- Infection Prevention by Modulation of Host Flora -- Enhancement of Resistance in the Immunocompromised Host by Control of Fungal Growth -- Nonvaccine Immunoalteration of the Host -- Passive Immunotherapy of Infectious Diseases: Lessons from the Past, Directions for the Future -- T-Cell Mediated Immunopathology in Viral Infections -- New Diseases and Disease Epidemiology -- Adherence and Proliferation of Bacteria on Artificial Surfaces -- Current Knowledge of Chlamydia TWAR, and Important Cause of Pneumonia and Other Acute Respiratory Diseases -- Current Status of Antiviral Chemotherapy for Genital Herpes Simplex Infection: Its Impact on Disease Control -- Induction and Maintenance Therapy for Opportunistic Infections in Patients with AIDS -- New Technology and Drug Design -- Nucleic Acid Hybridization: A Rapid Method for the Diagnosis of Infectious Diseases -- New Technology and Immunospecific Reactions in Helminthic Diseases -- Molecular Targets of Chemotherapeutic Agents Against the Human Immunodeficiency Virus -- Modern Strategies in the Design of Antimicrobial Agents -- Future Development and Use of Antiinfective Chemotherapy -- The Future Challenge of Infectious Disease -- Barriers to Effective Antiinfective Therapy. The Perspective of a Clinical Pharmacologist -- Optimal Use of Antimicrobial Agents -- Views of Future Antiinfective Therapy