1 Introduction -- 2 The Spectram of Inflammatory Demyelinating Diseases -- 2.1 Experimental Models -- 2.2 Human Diseases -- 3 Allergic Encephalomyelitis in Humans -- 4 The Pathology of Inflammatory Demyelinating Lesions -- 4.1 Inflammatory Reaction -- 4.2 Vascular Pathology -- 4.3 Blood-Brain Barrier -- 4.4 Demyelination and Myelin Degradation -- 4.5 The Fate of Oligodendroglia -- 4.6 Remyelination -- 4.7 Sclerosis -- 4.8 Axonal and Neuronal Pathology -- 4.9 Meningeal Pathology -- 4.10 Peripheral Nervous System Pathology -- 4.11 Patterns of Plaque Growth -- 4.12 Lesional Topography in the CNS -- 4.13 The Variability of Inflammatory Demyelinating Lesions -- 4.14 EAE as a Model of Human Inflammatory Demyelinating Diseases -- 5 Immunopathogenetic Considerations -- 5.1 Transfer Studies -- 5.2 The Possible Role of Autoantigens in the Pathogenesis of Inflammatory Demyelinating Lesions -- 5.3 Conclusions -- 6 Addendum: Material and Methods โ{128}{148} Models of Chronic EAE -- 6.1 Material and Methods -- 6.2 Factors Modifying the Development of Chronic EAE Models -- 7 References