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AuthorRusso, Jose. author
TitleMolecular Basis of Breast Cancer [electronic resource] : Prevention and Treatment / by Jose Russo, Irma H. Russo
ImprintBerlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2004
Connect tohttp://dx.doi.org/10.1007/978-3-642-18736-0
Descript XIV, 448 p. 1503 illus., 1278 illus. in color. online resource

SUMMARY

book, whose goal is to comprehensively review in ten During the past 30 years we have witnessed the emerยญ chapters the fundamental knowledge on breast canยญ gence of new disciplines whose contribution to the understanding of the biology of breast cancer have cer. The opening chapter links epidemiology, influยญ been enormous. Advances in the field of steroid horยญ ence of geographic and environmental exposures on mone nuclear receptors, which control the expression cancer incidence to the development of the organ and of genetic programs involved in cellular processes its role in cancer initiation. Central to this approach that are essential for normal and aberrant cell is the endocrine control of breast development, the growth, have been major contributors to the therapy relationship of cell proliferation with the presence of and prevention of hormone-dependent cancers. The steroid hormone receptors in the breast epithelium, and finally the importance of full differentiation as a discoveries of the association of hereditary breast cancers with mutations in the BRCAl and BRCA2 tool for protecting the breast from developing cancer. genes, and the concept that they essentially represent Reported are studies of the pathogenesis of breast a continuum of mutations with different degrees of cancer that have elucidated the site of origin of breast penetrance within given families, have added considยญ cancer and have been validated by in vitro experiยญ erable understanding to the molecular basis of breast mentation


CONTENT

Epidemiology of breast cancer -- The breast as a developing organ -- Endocrine control of the breast -- The role of estrogens in breast cancer -- Pathogenesis of breast cancer -- Prognostic and predictive factors in breast cancer -- The impact of the human genomic project on breast cancer -- The role of experimental models of breast cancer -- Preventive strategies in breast cancer -- New paradigms in the prevention of breast cancer -- Biological laws that determine the susceptibility and refractoriness of the breast to cancer


Medicine Cancer research Gynecology Oncology Medicine & Public Health Oncology Cancer Research Gynecology



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