1 Basics of Lymphology -- 1.1 Embryology and Anatomy -- 1.2 Physiology and Pathophysiology -- References -- 2 Lymphogenic Metastatic Spread -- 2.1 Squamous Cell Carcinomas -- 2.2 Malignant Melanoma -- 2.3 Merkel Cell Carcinoma -- 2.4 Carcinomas of the Salivary Glands -- 2.5 Carcinomas of the Thyroid Gland -- References -- 3 The Pathology of Lymphogenic Metastatic Spread -- 3.1 Examination Methods -- 3.2 Squamous Cell Carcinomas of the Head and Neck -- 3.3 Metastases of Salivary Gland Tumors and Thyroid Gland Carcinomas -- 3.4 Uncommon Cervical Lymph Node Metastases -- 3.5 Non-Neoplastic Reactive Lymph Node Alterations -- References -- 4 Diagnostic Techniques -- 4.1 Introduction -- 4.2 Inspection and Palpation -- 4.3 B-Mode Sonography -- 4.4 Computed Tomography and Magnetic Resonance Imaging -- 4.5 Lymphoscintigraphy -- 4.6 Positron Emission Tomography -- 4.7 Lymphography -- 4.8 Lymph Node Biopsy -- 4.9 Conclusion -- References -- 5 Principles of Surgery -- 5.1 History and Classification of the Surgical Treatment of Cervicofacial Lymph Node Metastases -- 5.2 Decision Points in Neck Dissection -- 6 Radiation Therapy: Principles and Treatment -- 6.1 Elective Neck Irradiation -- 6.2 Postoperative Radiation of the Node Positive Neck -- 6.3 Intensity-Modulated Radiation Therapy -- 6.4 Future Potential Applications -- References -- 7 Surgical Treatment Concepts -- 7.1 The Role of Neck Dissection in the Treatment of Squamous Cell Carcinomas of the Upper Aerodigestive Tract -- 7.2 Neck Dissection for Lymphoepithelial Carcinomas -- Neck Dissection for Skin Malignancies -- 7.4 Neck Dissection for Carcinomas of the Salivary Glands -- 7.5 Neck Dissection for Carcinomas of the Thyroid Gland -- 7.6 Sentinel Node Biopsy -- 7.7 Conclusion -- References -- 8 Complications -- 8.1 Surgical Complications -- 8.2 Complications from Radiation Therapy -- References -- 9 Cancer of Unknown Primary Sites -- 9.1 General Considerations -- 9.2 Topography of Lymph Node Metastases in Cancer of Unknown Primary -- 9.3 Diagnostics -- 9.4 Prognosis in Patients with Cancer of Unknown Primary Site -- 9.5 Treatment Concepts of Lymph Node Metastases in Sqamous Cell Carcinoma of Unknown Primary Site -- 9.6 Treatment Concepts of Lymph Node Metastases in Adenocarcinoma -- 9.7 Treatment Concepts of Lymph Node Metastases in Occult Malignant Melanoma -- 9.8 Value of Post-Therapeutic Appearance of the Primary Cancer -- 9.9 Branchiogenic Carcinoma -- References -- 10 Distant Metastases -- 10.1 Nasopharynx -- 10.2 Lips and Anterior Oral Cavity -- 10.3 Oropharynx -- 10.4 Larynx and Hypopharynx -- 10.5 Cervical Esophagus -- 10.6 Salivary Glands -- 10.7 Thyroid Gland -- References -- 11 Post-Therapeutic Follow-Up Principles -- 11.1 General Considerations -- 11.2 Follow-Up Interval -- 11.3 Type, Extent and Costs of Follow-up Examinations -- References